11 Result(s)
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Yaeko Nakajima-Takagi
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Article
Open AccessCorrection: UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
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Open AccessUTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
UTX/KDM6A, a histone H3K27 demethylase and a key component of the COMPASS complex, is frequently lost or mutated in cancer; however, its tumor suppressor function remains largely uncharacterized in multiple my...
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The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms
Dysfunctional anti-tumor immunity has been implicated in the pathogenesis of mature B cell neoplasms, such as multiple myeloma and B cell lymphoma; however, the impact of exhausted T cells on disease developme...
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Open AccessPCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Polycomb group proteins (PcG), polycomb repressive complexes 1 and 2 (PRC1 and 2), repress lineage inappropriate genes during development to maintain proper cellular identities. It has been recognized that PRC...
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Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation
The identification of characteristic differences between cancer stem cells and their normal counterparts remains a key challenge for cancer treatment. Here, we investigated the role of immunoglobulin superfami...
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Open AccessEpigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells
Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we present an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitor...
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Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis
Insufficiency of polycomb repressive complex 2 (PRC2), which trimethylates histone H3 at lysine 27, is frequently found in primary myelofibrosis and promotes the development of JAK2V617F-induced myelofibrosis ...
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PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome
EZH1 and EZH2 are enzymatic components of polycomb repressive complex (PRC) 2, which catalyzes histone H3K27 tri-methylation (H3K27me3) to repress the transcription of PRC2 target genes. We previously reported...
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Open AccessThe combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells
The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and i...
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Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
Junko Takita, Seishi Ogawa and colleagues profile 121 cases of pediatric T cell acute lymphoblasic leukemia (T-ALL) and identify recurrent SPI1 (PU.1) gene fusions. They find that these SPI1 fusions correlated wi...
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Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development
During T-cell development, Cd8 expression is controlled via dynamic regulation of its cis-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated Cd8 expression in CD4+CD8+ double-posit...
