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Article
Miniature mass spectrometer–based point-of-care assay for quantification of metformin and sitagliptin in human blood and urine
Metformin (MET) and sitagliptin (STG) are widely used as the first-line and long-term oral hypoglycemic agents for managing type 2 diabetes mellitus (T2DM). However, the current lack of convenient and rapid me...
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Article
Open AccessLC-MS/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy
Immunoglobulin A nephropathy (IgAN), a globally common primary chronic glomerulopathy, is one of the leading causes of end-stage renal disease. However, the underlying mechanisms of IgAN have yet to be demonst...
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Article
Open AccessProbabilistic analysis of long-term loss incorporating maximum entropy method and analytical higher-order moments
Quantifying economic losses of civil infrastructures subjected to various hazards under a life-cycle context is of vital importance for risk assessment and management. In previous studies, the expected long-te...
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Article
Open AccessLong-term loss assessment of coastal bridges from hurricanes incorporating overturning failure mode
Coastal highway bridge is an essential component of the transportation system but threatened by natural hazards such as hurricanes. Damaged highway bridges result in not only transportation disruption, but als...
