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Yanyan **a
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Article
Dual-mode colorimetric electrochemical aptamer sensor based on Au@Pd bimetallic nanoparticles for the detection of Pb(II) in edible mushrooms
Pb(II) can accumulate in the body and gradually cause irreversible harm. In this work, a dual-mode colorimetric biosensor based on an aptamer was developed as an effective method for sensitive sensing of Pb(II...
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Giant Topological Bandgap and Rashba Effect in Decorated Plumbene: A First-Principles Study
Materials with large Rashba spin splitting (RSS) and quantum spin Hall effect (QSHE) are extremely important in spintronic device applications. Based on first-principles calculations, we present H–Pb–OH, a two...
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Open AccessLow-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes
Long-read sequencing, exemplified by PacBio, revolutionizes genomics, overcoming challenges like repetitive sequences. However, the high DNA requirement ( > 1 µg) is prohibitive for small organisms. We develop...
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TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by a grim prognosis and numerous challenges. The objective of our study was to examine the role of thymidylate synthase (TYMS) in TNBC and its impact on fe...
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Open AccessIs face and information availability important in green purchasing among young consumers?
With the growing awareness of environmental issues available across various media platforms, consumers, particularly the younger generation, are more conscious of their consumption and its impact on the enviro...
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Open AccessIntegrating single-nucleus RNA sequencing and spatial transcriptomics to elucidate a specialized subpopulation of astrocytes, microglia and vascular cells in brains of mouse model of lipopolysaccharide-induced sepsis-associated encephalopathy
Understanding the mechanism behind sepsis-associated encephalopathy (SAE) remains a formidable task. This study endeavors to shed light on the complex cellular and molecular alterations that occur in the brain...
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Open AccessDesigning a highly efficient type III polyketide whole-cell catalyst with minimized byproduct formation
Polyketide synthases (PKSs) are classified into three types based on their enzyme structures. Among them, type III PKSs, catalyzing the iterative condensation of malonyl-coenzyme A (CoA) with a CoA-linked star...
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Open AccessNusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China
To evaluate the effectiveness and safety of nusinersen for the treatment of 5q-spinal muscular atrophy (SMA) among Chinese pediatric patients.
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Open AccessRelaxin combined with transarterial chemoembolization achieved synergistic effects and inhibited liver cancer metastasis in a rabbit VX2 model
To explore the effect and mechanism of relaxin (RLX) in the growth and metastasis of livercancer after combination treatment with transarterial chemoembolization (TACE).
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Open AccessRSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway
Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies and seriously threaten people’s health. Current therapies include bone marrow transplantation and several hypomethylating agents. However, ...
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Open AccessUse of ultrasound imaging Omics in predicting molecular ty** and assessing the risk of postoperative recurrence in breast cancer
The aim of this study is to assess the efficacy of a multiparametric ultrasound imaging omics model in predicting the risk of postoperative recurrence and molecular ty** of breast cancer.
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The combined effect of root morphological and resistance traits alleviated the growth limitations of Pinus massoniana seedlings under low phosphorus conditions
Understanding the adaptive strategies of plants to phosphorus (P) deficiency, particularly the plasticity of structural and physiological responses, is crucial for predicting plant growth. Our study aimed to i...
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Open AccessFunctional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model
Hepatocellular carcinoma (HCC) is among the most common malignancies worldwide and is characterized by high rates of morbidity and mortality, posing a serious threat to human health. Interventional embolizatio...
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Analysis of biopsy pathology and risk factors of lymph node metastasis in prostate cancer
To explore the relationship between biopsy pathology and lymph node metastasis in patients with prostate cancer (PCa), and to identify risk factors of lymph node metastasis (LNM).
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Tessellated fundus occurs earlier than myopia in children aged 3–6 years
Tessellated fundus can exist in normal healthy eyes. This study aims to evaluate the occurrence and influencing factors of tessellated fundus in preschool children aged 3–6 years.
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A fuzzy rough set-based undersampling approach for imbalanced data
How to effectively handle imbalanced data is one of the hot issues in the fields of machine learning and data mining. Undersampling is a popular technique of dealing with imbalanced data. The aim of undersampl...
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Undergoing Lung Surgery (PSA-Lung) was appropriate for symptom assessment after discharge
To examine whether a 7-day or 24-h recall period of Perioperative Symptom Assessment for Patients Undergoing Lung Surgery (PSA-Lung) was appropriate for symptom assessment after discharge.
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Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
A strong immunosuppressive tumor microenvironment (TME) represents the major barrier responsible for the failure of current immunotherapy approaches in treating Glioblastoma Multiforme (GBM). Within the TME, t...
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Open AccessRevisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression
Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME). Mesenchymal stromal cells (MSCs) play a pivotal role in cancer...
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MOF-templated tubular Ni1-xCoxS2-CdS heterojunction with intensified direct Z-scheme charge transmission for highly promoted visible-light photocatalysis
Hollow semiconductor nanostructures with direct Z-scheme heterojunction have significant advantages for photocatalytic reactions, and optimizing the interfacial charge transmission of Z-scheme heterojunction i...
