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Article
Open AccessLow-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes
Long-read sequencing, exemplified by PacBio, revolutionizes genomics, overcoming challenges like repetitive sequences. However, the high DNA requirement ( > 1 µg) is prohibitive for small organisms. We develop...
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Article
Open AccessHagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hyp...
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Article
Open AccessDNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans
Despite long being considered as “junk”, transposable elements (TEs) are now accepted as catalysts of evolution. One example is Mutator-like elements (MULEs, one type of terminal inverted repeat DNA TEs, or TIR T...
