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Article
Open AccessPolymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial
The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance.
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Article
A multi-model prediction system for ENSO
The El Niño and Southern Oscillation (ENSO) is the primary source of predictability for seasonal climate prediction. To improve the ENSO prediction skill, we established a multi-model ensemble (MME) prediction...
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Article
Open AccessIncidence, clinical characteristics, risk factors and outcomes of patients with mixed Candida/bacterial bloodstream infections: a retrospective study
The mixed Candida/bacterial bloodstream infections (mixed C/B-BSIs) is worthy of particular attention recently, and we analyzed the incidence, co-pathogens, clinical characteristics, risk factors, and outcomes of...
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Article
Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis
The study aims to clarify the expression pattern of MIR3142HG in acute lung injury (ALI) and investigate the potential mechanisms for the regulatory role of MIR3142HG in JAK/STAT in ALI. Notably, the ALI patie...
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Article
Open AccessReal-world effectiveness of primary screening with high-risk human papillomavirus testing in the cervical cancer screening programme in China: a nationwide, population-based study
Randomized controlled trials have shown a higher sensitivity and longer negative predictive value of high-risk human papillomavirus (HPV) testing than cytology for cervical cancer screening; however, little is...
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Article
Open AccessAn extension of LDEO5 model for ENSO ensemble predictions
This study provided an extension to the latest version of Lamont-Doherty Earth Observation (LDEO5) prediction system. First, an ensemble coupled data assimilation (CDA) system, based on the Ensemble Kalman Fil...
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Article
Open AccessThe relationship among probabilistic, deterministic and potential skills in predicting the ENSO for the past 161 years
Here, we explored in depth the relationship among the deterministic prediction skill, the probabilistic prediction skill and the potential predictability. This was achieved by theoretical analyses and, in part...
