-
Article
Open AccessA case of endocardial dissection caused by Micra implantation
Leadless pacemakers are a recent technological advancement. It has many advantages, but there are still a few serious complications.
-
Article
Open AccessRight ventriculography improves the accuracy of leadless pacemaker implantation in right ventricular mid-septum
Implanting leadless pacemakers in the right ventricular (RV) apex is prone to causing pericardial tamponade and myocardial perforation.
-
Article
Open AccessPostcardiac injury syndrome caused by radiofrequency catheter ablation of persistent atrial fibrillation: severe pulmonary arterial hypertension with severe tricuspid regurgitation: a rare case report and literature review
Postcardiac injury syndrome (PCIS) is an easy-to-miss diagnosis, but it is not an uncommon complication. The phenomenon of echocardiography (ECHO) showing both severe pulmonary arterial hypertension (PAH) and ...
-
Article
Open AccessClinical enrollment assay to detect preexisting neutralizing antibodies to AAV6 with demonstrated transgene expression in gene therapy trials
Recombinant adeno-associated virus (AAV) vectors are the leading platform for gene delivery for a variety of clinical applications. Patients with preexisting antibodies to AAV are currently excluded from most ...
-
Article
Open AccessOptimization for ultrasonic-microwave synergetic extraction of total iridoid glycosides and screening of analgesic and anti-inflammatory active fractions from patrinia scabra Bunge (Valerianaceae)
Patrinia scabra Bunge is a well-known herbal medicine for its favorable treatment on inflammatory diseases owing to its effective ingredients, in which iridoid glycoside plays an extremely significant role. This ...
-
Article
Open AccessCharacterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ
Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglob...
-
Article
Open AccessScreening of differentially expressed microRNAs of essential hypertension in Uyghur population
Essential hypertension can cause many kinds of cardiovascular diseases. The pathogenesis of essential hypertension is very complex, and the mechanism is still unclear. The microRNAs have been identified as nov...
-
Article
Open AccessEpidemiological investigation of sudden cardiac death in multiethnic **njiang Uyghur autonomous region in Northwest China
The epidemiological characteristics of sudden cardiac death (SCD) in the autonomous region of **njiang Uygur have been largely unknown. This study aimed to evaluate the incidence and demographic risk factors o...
-
Article
Open AccessEthnicity and anticoagulation management of hospitalized patients with atrial fibrillation in northwest China
The therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized ...
-
Protocol
Quantitation of Circulating Neuropilin-1 in Human, Monkey, Mouse, and Rat Sera by ELISA
Neuropilin-1 (NRP1) is a single spanning transmembrane glycoprotein that acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factors. Naturally occurring soluble NRP1 isoforms contain...
-
Article
Open AccessHutchinson-Gilford progeria syndrome accompanied by severe skeletal abnormalities in two Chinese siblings: two case reports
Hutchinson-Gilford progeria syndrome is a rare pediatric genetic syndrome with an incidence of one per eight million live births. The disorder is characterized by premature aging, generally leading to death du...
-
Article
Anti-Neuropilin-1 (MNRP1685A): Unexpected Pharmacokinetic Differences Across Species, from Preclinical Models to Humans
To compare the pharmacokinetics (PK) of MNRP1685A, a human monoclonal antibody (mAb) against neuropilin-1 (NRP1), in mice, rats, monkeys, and cancer patients from a Phase I study to model with parallel linear ...
-
Article
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
A coding mutation in APP, the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.
-
Article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Systemic toxicity associated with heterogeneity in the stoichiometries and sites of drug attachment is a major hurdle to develo** antibody-drug conjugates (ADCs) for cancer therapy. Junutula et al. engineer cys...
