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Article
Open AccessCharacterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ
Accumulation of amyloid β (Aβ) in the brain is proposed as a cause of Alzheimer’s disease (AD), with Aβ oligomers hypothesized to be the primary mediators of neurotoxicity. Crenezumab is a humanized immunoglob...
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Article
Open AccessStructure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin
Accumulation of amyloid-β (Aβ) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer’s disease (AD). The precise pathological species of Aβ remains elusive although evidence sug...
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Article
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Mutations in UNC5C are identified in individuals with late-onset Alzheimer's disease and increase susceptibility of neurons to cell death.
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Article
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
A coding mutation in APP, the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.
