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Article
Open AccessDetection of AZF microdeletions and analysis of reproductive hormonal profiles in Hainan men undergoing assisted reproductive technology
Male infertility has become a global health problem, and genetic factors are one of the essential causes. Y chromosome microdeletion is the leading genetic factor cause of male infertility. The objective of th...
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Article
Open AccessLysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor
Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...
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Article
The Effect of the cAMP Signaling Pathway on HTR8/SV-Neo Cell Line Proliferation, Invasion, and Migration After Treatment with Forskolin
Pre-eclampsia (PE) is thought to be related to placental dysfunction, particularly poor extravillous trophoblast (EVT) invasion and migration abilities. However, the pathogenic mechanism is not fully understoo...
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Article
Effect of Cyclosporine A on Th1/Th2 Cytokine Production by Decidual Stromal Cells Mediated by Trophoblast-derived Galectin-9
This study aimed to investigate the effect of cyclosporine A (CsA) on secretion of Th1 and Th2 cytokines by decidual stromal cells (DSCs) mediated by galectin (Gal)-9.HTR8/SVneo cells and primary trophoblasts ...
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Article
Regulation effects of water and nitrogen on yield, water, and nitrogen use efficiency of wolfberry
Wolfberry (Lycium barbarum L.) is important for health care and ecological protection. However, it faces problems of low productivity and resource utilization during planting. Exploring reasonable models for wate...
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Article
Open AccessImpacts of different culture times on pregnancy outcomes after thawing of cleavage stage embryos
This study assessed the impacts of in vitro culture times of cleavage embryos on clinical pregnancy outcomes.
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Article
Open AccessHistone acetyltransferase CSRP2BP promotes the epithelial–mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin
Dysregulated epithelial–mesenchymal transition (EMT) is involved in cervical cancer metastasis and associated with histone acetylation. However, the underlying molecular mechanisms of histone acetylation in ce...
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Article
Open AccessDeciphering early human pancreas development at the single-cell level
Understanding pancreas development can provide clues for better treatments of pancreatic diseases. However, the molecular heterogeneity and developmental trajectory of the early human pancreas are poorly explo...
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Article
Open AccessSingle-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage
The lung is the primary respiratory organ in human, in which the proximal airway and the distal alveoli are responsible for air conduction and gas exchange, respectively. However, the regulation of proximal–di...
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Article
Open AccessSingle-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer
RNA-binding proteins (RBPs) are key players of gene expression and perturbations of RBP-RNA regulatory network have been observed in various cancer types. Here, we propose a computational method, RBPreg, to id...
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Analysis of Chemokine-to-GAG Interactions in Model of Donor Renal Allograft Transplant
Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct immune cell responses initiating local ...
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Article
Open AccessPan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications
The tripartite motif (TRIM) proteins function as important regulators in innate immunity, tumorigenesis, cell differentiation and ontogenetic development. However, we still lack knowledge about the genetic and...
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Article
Open AccessAcylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39
Epithelial ovarian cancer (EOC) is the leading cause of deaths among patients with gynecologic malignancies. In recent years, cancer stem cells (CSCs) have attracted great attention, which have been regarded a...
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Article
Open AccessGenetic correction of concurrent α- and β-thalassemia patient-derived pluripotent stem cells by the CRISPR-Cas9 technology
Thalassemia is a genetic blood disorder characterized by decreased hemoglobin production. Severe anemia can damage organs and severe threat to life safety. Allogeneic transplantation of bone marrow-derived hem...
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Article
Number of Blastomeres in Day-2 Embryos Affect the Rates of Blastocyst Formation and Clinical Pregnancy During In Vitro Fertilization Cycles
In the current in vitro fertilization and embryo transfer protocol, the 8 blastomeres in the day-3 embryo are selected for transfer because these embryos can produce high rates of blastocyst formation and clin...
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Article
Prevalence and molecular spectrum of α- and β-globin gene mutations in Hainan, China
This study investigated prenatal diagnosis of α-thalassemia and β-thalassemia in 3049 families in 18 regions of Hainan Province. Molecular diagnosis was performed in 3049 couples with thalassemia in Hainan Pro...
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Article
Synthesis and luminescence properties of red-emitting NaBaBi2(PO4)3:Eu3+ phosphors
In this study, a series of Eu3+-doped NaBaBi2(PO4)3 red phosphors were synthesized by high-temperature solid-phase reaction method, and the phase structure and photoluminescence properties of the samples were inv...
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Article
Open AccessWhole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a...
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Article
Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies
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Article
Electrokinetic remediation of antibiotic-polluted soil with different concentrations of tetracyclines
This study investigated the efficacy of electrokinetic remediation of soils polluted with different concentrations of tetracyclines (TCs). Three widely used TCs (oxytetracycline, chlortetracycline, and tetracy...
