Skip to main content

5 Result(s)

within Yange Niu Remove this filter

and

  1. Article

    Open Access

    Structures of human SGLT in the occluded state reveal conformational changes during sugar transport

    Sodium-Glucose Cotransporters (SGLT) mediate the uphill uptake of extracellular sugars and play fundamental roles in sugar metabolism. Although their structures in inward-open and outward-open conformations ar...

    Wenhao Cui, Yange Niu, Zejian Sun, Rui Liu, Lei Chen in Nature Communications (2023)

    Download PDF (2148 KB) View Article

  2. Article

    Open Access

    Structural mechanism of SGLT1 inhibitors

    Sodium glucose co-transporters (SGLT) harness the electrochemical gradient of sodium to drive the uphill transport of glucose across the plasma membrane. Human SGLT1 (hSGLT1) plays a key role in sugar uptake f...

    Yange Niu, Wenhao Cui, Rui Liu, Sanshan Wang, Han Ke… in Nature Communications (2022)

    Download PDF (2184 KB) View Article

  3. No Access

    Article

    Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

    Human sodium–glucose cotransporter 2 (hSGLT2) mediates the reabsorption of the majority of filtrated glucose in the kidney1. Pharmacological inhibition of hSGLT2 by oral small-molecule inhibitors, such as empagli...

    Yange Niu, Rui Liu, Chengcheng Guan, Yuan Zhang, Zhixing Chen, Stefan Hoerer… in Nature (2022)

  4. Article

    Open Access

    Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

    Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cho...

    Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang… in Nature Communications (2020)

    Download PDF (1905 KB) View Article

  5. Article

    Immunogenicity of multi-epitope-based vaccine candidates administered with the adjuvant Gp96 against rabies

    Rabies, a zoonotic disease, causes > 55,000 human deaths globally and results in at least 500 million dollars in losses every year. The currently available rabies vaccines are mainly inactivated and attenuated...

    Yange Niu, Ye Liu, Limin Yang, Hongren Qu, **gyi Zhao, Rongliang Hu… in Virologica Sinica (2016)

    Download PDF (399 KB)