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  1. No Access

    Article

    Whole-exome sequencing analysis to identify novel potential pathogenetic NPC1 mutations in two Chinese families with Niemann–Pick disease type C

    Niemann–Pick disease type C (NPC) is an autosomal recessive lipid storage disorder, affecting the nervous system and the internal organs. It is characterized by the presence of foam cells in bone marrow, liver...

    Chengcheng Guan, **nhui Gan, Chengqing Yang, Mingji Yi, Ying Zhang… in Neurological Sciences (2022)

  2. No Access

    Article

    Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

    Human sodium–glucose cotransporter 2 (hSGLT2) mediates the reabsorption of the majority of filtrated glucose in the kidney1. Pharmacological inhibition of hSGLT2 by oral small-molecule inhibitors, such as empagli...

    Yange Niu, Rui Liu, Chengcheng Guan, Yuan Zhang, Zhixing Chen, Stefan Hoerer… in Nature (2022)

  3. Article

    Open Access

    Association between polymorphisms rs2228001 and rs2228000 in XPC and genetic susceptibility to preeclampsia: a case control study

    Xeroderma pigmentosum complementation group C (XPC) is a DNA damage recognition protein that plays an important role in nucleotide excision repair and can reduce oxidative stress, which may be involved in the ...

    **gli Wang, Chengcheng Guan, **g Sui, Yucui Zang… in BMC Pregnancy and Childbirth (2021)

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  4. Article

    Open Access

    Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

    Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cho...

    Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang… in Nature Communications (2020)

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