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Article
Ursodeoxycholic Acid Enhances the Antibacterial Activity of Colistin by Inhibiting MCR-1
Colistin is recognized as the “last line of defense” for the treatment of carbapenemase-producing “super-resistant” bacteria. However, the treatment of clinical bacterial infections has become more challenging...
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Article
Open AccessAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, ...
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Chapter and Conference Paper
Multi-scale Dilated Attention Graph Convolutional Network for Skeleton-Based Action Recognition
Due to the small size, anti-interference and strong robustness of skeletal data, research on human skeleton-based action recognition has become a mainstream. However, due to the incomplete utilization of seman...
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Article
Selenium metabolism heterogeneity in pan-cancer: insights from bulk and single-cell RNA sequencing
Selenium, a natural microelement with both nutritional and toxicological properties, is intertwined with tumorigenesis and progression. However, it is not fully understood how selenium metabolism affects immun...
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Article
Comprehensive analysis of CDK5 as a novel biomarker for progression in esophageal cancer
Cyclin-dependent kinase 5 (CDK5) is a member of the cyclin-dependent kinase family, and unlike the rest of the members of the family, its kinase activity is independent of cyclins. Accumulating evidence has sh...
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Chapter and Conference Paper
Optimization and Performance Evaluation of Plugging Scheme for Fracture Leakage in Gas Storage Drilling
Serious fracture leakage often occurs in the drilling process of gas storage construction in Jidong oilfield. Because of the mismatch between plugging formula and the formation, the plugging effect is not good...
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Article
Open AccessImbalance of Th17, Treg, and helper innate lymphoid cell in the peripheral blood of patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease involving a variety of immune cells, including adaptive T and B cells and innate lymphoid cells (ILCs). Understanding the pathogenic role of these im...
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Article
Open AccessPan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics ...
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Article
Open AccessCutting Behavior of Cortical Bone in Different Bone Osteon Cutting Angles and Depths of Cut
Cortical bone is semi-brittle and anisotropic, that brings a challenge to suppress vibration and avoid undesired fracture in precise cutting process in surgeries. In this paper, a novel analytical model is pro...
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Article
Open AccessSpatio-temporal evolution and driving factors of carbon storage in the Western Sichuan Plateau
The carbon sequestration function of the ecosystem is one of the most important functions of ecosystem service, and it of great significance to study the spatio-temporal differentiation of carbon storage for p...
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Article
Open AccessThrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still...
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Article
Triplet-object loss for large scale deep image retrieval
Deep hashing has been widely applied in large scale image retrieval due to its high computation efficiency and retrieval performance. Recently, training deep hashing networks with a triplet ranking loss become...
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Article
Fabrication of large-scale infrared diffractive lens arrays on chalcogenide glass by means of step-and-repeat hot imprinting and non-isothermal glass molding
In this study, a new cost-effective and high-precision process chain for the fabrication of large-scale infrared (IR) diffractive lens arrays on chalcogenide glass is proposed. First, a positive diffractive le...
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Article
Preparation and in vitro bioactive evaluation of cashew-nut proteins hydrolysate as a potential source of anti-allergy peptides
This work proposes a novel potential source of antiallergens based on bioactive peptides. Cashew-nut protein hydrolysate with antiallergic activity was prepared from cashew nuts through protease treatment. The...
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Article
“Switch-on” fluorescence sensing platform based on porphyrin metal-organic frameworks for rapid and specific detection of zinc ion
Zinc ion (Zn2+) is a necessary transition metal ion in the human body and plays a vital role in biological systems. Therefore, it is meaningful for rapid, sensitive, and specific detection of Zn2+. Herein, a “swi...
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Article
Open AccessPersonalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer
Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treat...
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Chapter and Conference Paper
Biomechanical Analysis of Different Foot Morphology During Standing on a Dynamic Support Surface
Foot is a significant element during the balance as the main organ that connects with surface. From the research of habitually barefoot people and habitually shod people, there were significant differences in ...
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Article
Open AccessPersonalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models
Development of personalized cancer vaccines based on neoantigens has become a new direction in cancer immunotherapy. Two forms of cancer vaccines have been widely studied: tumor-associated antigen (including p...
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Article
Experimental and Numerical Study on Failure Modes and Shear Strength Parameters of Rock-Like Specimens Containing Two Infilled Flaws
To investigate the influence of infilled flaws on mechanical properties and failure modes of rock masses, seven types of pre-existing infilled two-flaw specimens, which have different flaw inclination angle (α), ...
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Article
In situ fabrication of organic electrochemical transistors on a microfluidic chip
Microfluid chips integrating with organic electrochemical transistors (OECTs) are useful for manufacturing biosensors with high throughput and large-scale analyses. We report here the utilization of alternatin...
