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Article
Open AccessA potent Henipavirus cross-neutralizing antibody reveals a dynamic fusion-triggering pattern of the G-tetramer
The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between the attachment (G) and fusion (F) glycoproteins re...
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Article
Open AccessPotent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains
Nipah virus (NiV) is a World Health Organization priority pathogen and there are currently no approved drugs for clinical immunotherapy. Through the use of a naïve human phage-displayed Fab library, two neutra...
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Article
Open AccessBoth chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity and the lack of viable countermeasures. Vaccines are the most crucial defense against ...
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Article
Open AccessRBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates
The pandemic of COVID-19 caused by SARS-CoV-2 has raised a new challenges to the scientific and industrious fields after over 1-year spread across different countries. The ultimate approach to end the pandemic...
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Article
Open AccessCorrection to: Transmission of H7N9 influenza virus in mice by different infective routes
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Article
Open AccessA SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes
COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can provide an important treatment option to fight...
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Article
Open AccessCharacterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor b...
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Article
Open AccessCorrection to: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
An amendment to this paper has been published and can be accessed via the original article.
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Article
Avian Influenza A (H7N9) Virus in a Wild Land Bird in Central China, Late 2015
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Article
Characterization of a reassortant H11N9 subtype avian influenza virus isolated from bean goose along the East Asian–Australian flyway
During the surveillance of avian influenza viruses in the Dongxi Lake wetland of Hubei in 2015–2016, an H11N9 avian influenza virus was isolated from a bean goose (Anser fabalis). Phylogenetic analysis showed tha...
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Chapter and Conference Paper
Analysis of Platform and Payload Integrated Design Technology for Optical Remote Sensing Satellites
Driven by the goal of high resolution, high agility and low cost, the integrated design technology of satellite platform and payload considering payload as center is an important trend in the development of ad...
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Article
MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2
Middle East respiratory syndrome coronavirus (MERS-CoV) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. MERS is often complicated by acute respiratory distress syndrome (ARDS) an...
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Article
Distribution of enterovirus 71 RNA in inflammatory cells infiltrating different tissues in fatal cases of hand, foot, and mouth disease
In previous studies of hand, foot, and mouth disease patients fatally infected with enterovirus 71 (EV71), the distribution of viral protein, but not the genome, was determined. To understand the pathogenesis ...
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Article
Open AccessTransmission of H7N9 influenza virus in mice by different infective routes
On 19 February 2013, the first patient infected with a novel influenza A H7N9 virus from an avian source showed symptoms of sickness. More than 349 laboratory-confirmed cases and 109 deaths have been reported ...
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Article
Open AccessAn adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes serious problems in immunocompromised or immunologically immature hosts. Vaccination is the preferred approach for prevention of HCMV infection...
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Article
Comparative analysis of antibody induction and protection against influenza virus infection by DNA immunization with HA, HAe, and HA1 in mice
Plasmid DNA vaccines are considered alternatives to inactivated influenza virus vaccines to control influenza. Vaccination with a hemagglutinin (HA)-, HA ectodomain (HAe)-, or HA subunit 1 (HA1)-based vaccine...
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Article
Evaluation of neutralizing efficacy of monoclonal antibodies specific for 2009 pandemic H1N1 influenza A virus in vitro and in vivo
Pandemic influenza A virus (H1N1) 2009 poses a serious public-health challenge worldwide. To characterize the neutralizing epitopes of this virus, we generated a panel of eight monoclonal antibodies (mAbs) aga...
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Article
Open AccessThe mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
The current study was conducted to establish animal models (including mouse and ferret) for the novel avian-origin H7N9 influenza virus.
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Article
Immunization with cytomegalovirus envelope glycoprotein M and glycoprotein N DNA vaccines can provide mice with complete protection against a lethal murine cytomegalovirus challenge
Human cytomegalovirus virions contain three major glycoprotein complexes (gC I, II, III), all of which are required for CMV infectivity. These complexes also represent major antigenic targets for anti-viral im...
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Article
Characterization of low-pathogenic H6N6 avian influenza viruses in central China
Three strains of H6N6 subtype avian influenza virus (AIV) were isolated from live-poultry markets of central China during 2009-2010. A phylogenetic analysis showed that these isolates originated from gene reas...
