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Article
The Role of Colonic Microbiota in Lactose Intolerance
In a previous study we observed a clear difference in lactose intolerance symptoms after a 25-g lactose load in two groups of persons with lactase nonpersistence and similar small intestinal lactase activity. ...
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Article
The Validation of an LC-MS Method for the Determination of Risperidone and its Active Metabolite 9-Hydroxyrisperidone in Human Plasma
A simple, specific and sensitive high performance liquid chromatography-mass spectrometry (LC-MS) method for the determination of risperidone and its active metabolite 9-hydroxyrisperidone in human plasma has ...
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Article
Simple High-Performance Liquid Chromatographic Assay, with Post-Column Derivatization, for Simultaneous Determination of Mycophenolic Acid and its Glucuronide Metabolite in Human Plasma and Urine
Two simple high-performance liquid chromatographic (HPLC) methods have been established for simultaneous determination of mycophenolic acid (MPA) and its glucuronide metabolite (MPAG) in human urine, and of th...
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Article
Quantitative Analysis of Artemether and its Metabolite Dihydroartemisinin in Human Plasma by LC with Tandem Mass Spectrometry
We report the development and validation of a high-performance liquid-chromatographic–tandem mass spectrometric method for determination of artemether (ARM) and its active metabolite dihydroartemisinin (DHA) i...
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Article
LC-ESI-MS Method for the Determination of Mizolastine in Human Plasma
A sensitive and rapid liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method has been developed and validated for the determination of mizolastine in human plasma using dipyridamole...
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Indication and Procedure of Pancreatic and Bile Duct Stenting
Stenting is one of the most commonly practiced endoscopic procedures in the management of biliary and pancreatic disorders. Endoscopic stenting is the treatment of choice for biliary and pancreatic duct strict...
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Article
Syntheses, crystal structures and electrochemical properties of three organic-inorganic hybrid supramolecular compounds based on copper-complex fragments and different polyoxometalates
Three new organic–inorganic hybrid compounds H[CuI(dafo)2]3{[CuI(dafo)2]2P2W18O62} · H2O (1), [CuI(dafo)2]3PMo12O40 (2) and [CuI(dafo)2]4SiW12O40 (3) (dafo = 4, 5-diazafluoren-9-one) have been hydrothermally synt...
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Article
Open AccessImportant role of indels in somatic mutations of human cancer genes
Cancer is clonal proliferation that arises owing to mutations in a subset of genes that confer growth advantage. More and more cancer related genes are found to have accumulated somatic mutations. However, lit...
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Article
The association between non-Hodgkin lymphoma and methylation of p73
To investigate the effects of methylation of the p73 gene on the pathogenesis of non-Hodgkin lymphoma (NHL), the methylation status of the p73 gene promoter and the expression of p73 mRNA were examined in NHLs by...
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Article
Model systems and clinical applications of hepatic stem cells for liver regeneration
Hepatic stem cells are capable to self-renew and to differentiate into all types of cells in the liver, including hepatic progenitors, mature hepatocytes and cholangiocytes.
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Article
Open AccessVariation of presence/absence genes among Arabidopsis populations
Gene presence/absence (P/A) polymorphisms are commonly observed in plants and are important in individual adaptation and species differentiation. Detecting their abundance, distribution and variation among ind...
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Article
Open AccessFunctional requirements driving the gene duplication in 12 Drosophila species
Gene duplication supplies the raw materials for novel gene functions and many gene families arisen from duplication experience adaptive evolution. Most studies of young duplicates have focused on mammals, espe...
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Article
Significance of Serum Potassium Level Monitoring during the Course of Post-Operative Rehabilitation in Patients with Hypokalemia
Our objective was to evaluate the significance of pre-hospital and post-operative serum potassium level monitoring and hypokalemia intervention in laparotomy patients with hypokalemia.
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Article
Chemerin plays a protective role by regulating human umbilical vein endothelial cell-induced nitric oxide signaling in preeclampsia
The aim of this study was to determine chemerin levels in preeclampsia and to assess the effects of this anti-inflammatory factor on endothelial nitric oxide synthase (eNOS), nuclear factor (NF)-κB, and vascul...
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Article
Open AccessSpecies-specific duplications driving the recent expansion of NBS-LRR genes in five Rosaceae species
Disease resistance (R) genes from different Rosaceae species have been identified by map-based cloning for resistance breeding. However, there are few reports describing the pattern of R-gene evolution in Rosacea...
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Article
Open AccessSystematically dissecting the global mechanism of miRNA functions in mouse pluripotent stem cells
MicroRNAs (miRNAs) critically modulate stem cell properties like pluripotency, but the fundamental mechanism remains largely unknown.
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Article
Open AccessSerum screening in first trimester to predict pre-eclampsia, small for gestational age and preterm delivery: systematic review and meta-analysis
Early assessment before the establishment of placental dysfunction has the potential to improve treatment and prognosis for clinical practice.The objective of the study is to investigate the accuracy of serum ...
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Article
Open AccessSpecies-specific duplications of NBS-encoding genes in Chinese chestnut (Castanea mollissima)
The disease resistance (R) genes play an important role in protecting plants from infection by diverse pathogens in the environment. The nucleotide-binding site (NBS)-leucine-rich repeat (LRR) class of genes is o...
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Article
The Physiology of BDNF and Its Relationship with ADHD
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous system that plays a critical role in the physiological brain functions via its two independent receptors: tropomyosin-rel...
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Article
Open AccessSpecific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo
To investigate the antiviral effects of vectors expressing specific short hairpin RNAs (shRNAs) against Hantaan virus (HTNV) infection in vitro and in vivo.
