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Article
The minimum feature subset selection problem
In applications of learning from examples to real-world tasks, feature subset selection is important to speed up training and to improve generalization performance. Ideally, an inductive algorithm should use s...
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Article
A tough biodegradable elastomer
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility ...
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Article
Poly(glycerol sebacate)—A Novel Biodegradable Elastomer for Tissue Engineering
Biodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility ...
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Chapter and Conference Paper
A Novel Feature Ensemble Technology to Improve Prediction Performance of Multiple Heterogeneous Phenotypes Based on Microarray Data
Gene expression microarray technology provides the global information on transcriptional activities of essentially all genes simultaneously, and it thus promotes the new application of traditional feature sele...
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Article
Open AccessUnravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering
It becomes increasingly clear that our current taxonomy of clinical phenotypes is mixed with molecular heterogeneity. Of vital importance for refined clinical practice and improved intervention strategies is t...
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Article
Experimental Study on the Estrogen-Like Effect of Boric Acid
There are now considerable evidences that boric acid has reproductive and developmental toxicity, but it is uncertain whether such toxicity is caused by estrogen-like effect. Our objective is to determine the ...
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Article
Open AccessIdentification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome
This is a first report, using our MotifModeler informatics program, to simultaneously identify transcription factor (TF) and microRNA (miRNA) binding sites from gene expression microarray data. Based on the assum...
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Article
Experimental study on the estrogen-like effect of mercuric chloride
Although mercuric chloride has toxicity on reproductive system, it is uncertain if such toxicity is induced by estrogen-like effect. To study whether mercuric chloride has the estrogen-like effect and its rele...
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Article
Cardiac tissue engineering using perfusion bioreactor systems
This protocol describes tissue engineering of synchronously contractile cardiac constructs by culturing cardiac cell populations on porous scaffolds (in some cases with an array of channels) and bioreactors wi...
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Article
Open AccessConstructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements
With the advance of large-scale omics technologies, it is now feasible to reversely engineer the underlying genetic networks that describe the complex interplays of molecular elements that lead to complex dise...
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Article
Open AccessTranscription factor and microRNA regulation in androgen-dependent and -independent prostate cancer cells
Prostate cancer is one of the leading causes of cancer death in men. Androgen ablation, the most commonly-used therapy for progressive prostate cancer, is ineffective once the cancer cells become androgen-inde...
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Chapter and Conference Paper
Global Similarity and Local Variance in Human Gene Coexpression Networks
For the study presented here, we performed a comparative analysis of whole-genome gene expression variation in 210 unrelated HapMap individuals to assess the extent of expression divergence between 4 human pop...
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Article
Open AccessReconstruct gene regulatory network using slice pattern model
Gene expression time series array data has become a useful resource for investigating gene functions and the interactions between genes. However, the gene expression arrays are always mixed with noise, and man...
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Article
Open AccessPrioritization of disease microRNAs through a human phenome-microRNAome network
The identification of disease-related microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools for diagnosis, treatment a...
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Article
A proof of the convergence theorem of maximum-entropy clustering algorithm
In this paper, we point out that the counterexample constructed by Yu et al. is incorrect by using scientific computing software Sage. This means that the example cannot negate the convergence theorem of maxim...
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Article
Cenozoic tectonic evolution in the western Qaidam Basin inferred from subsurface data
It is an agreement that collision of Indian and Asian plates causes uplift of the Tibet Plateau. However, great controversy exists about uplifting history and mechanisms of the Tibetan Plateau. Uplift history ...
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Article
Current Density Dependence of Transient Electroluminescence in Phosphorescent Organic Light-Emitting Diodes
The transient electroluminescence (EL) of phosphorescent organic light-emitting diodes (OLEDs) was investigated. The behaviors of the transient characteristics are analyzed using the triplet-triplet annihilati...
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Chapter
Bioelastomers in Tissue Engineering
The rapid progress in cell and developmental biology has clearly revealed that substrate elasticity and mechanical stimulation significantly affect cell function and tissue development. Further, many engineere...
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Article
Open AccessA modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer
Estrogens regulate diverse physiological processes in various tissues through genomic and non-genomic mechanisms that result in activation or repression of gene expression. Transcription regulation upon estrog...
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Article
Open AccessChromatin structure characteristics of pre-miRNA genomic sequences
MicroRNAs (miRNAs) are non-coding RNAs with important roles in regulating gene expression. Recent studies indicate that transcription and cleavage of miRNA are coupled, and that chromatin structure may influen...
