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  1. No Access

    Article

    Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke

    The phenotypic transformation of microglia in the ischemic penumbra determines the outcomes of ischemic stroke. Our previous study has shown that chemokine-like-factor 1 (CKLF1) promotes M1-type polarization o...

    **n Zhou, Ya-ni Zhang, Fang-fang Li, Zhao Zhang, Li-yuan Cui… in Acta Pharmacologica Sinica (2022)

  2. Article

    Open Access

    Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

    The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide ...

    Qing-Qing Xu, Yan-Zhen Lai, Zi-Lu Huang, Zi-Yi Zeng, Ya-Ni Zhang… in Radiation Oncology (2021)

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  3. Article

    Open Access

    Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis

    X-linked agammaglobulinaemia (XLA) is a rare inherited primary immunodeficiency disease characterized by the B cell developmental defect, caused by mutations in the gene coding for Bruton’s tyrosine kinase (BT...

    Ya-Ni Zhang, Yuan-Yuan Gao, Si-Da Yang, Bin-Bin Cao, Ke-Lu Zheng, ** Wei… in BMC Neurology (2019)

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  4. No Access

    Article

    Mycoplasma contamination-mediated attenuation of plasmid DNA transfection efficiency is augmented via l-arginine deprivation in HEK-293 cells

    明确支原体污染对HEK-293 细胞质粒DNA 转染 效率的影响, 并从支原体对细胞精氨酸代谢的角 度探究其机制。

    Zi-fei Yin, Ya-ni Zhang, Shu-fang Liang… in Journal of Zhejiang University-SCIENCE B (2019)

  5. Article

    Open Access

    Acupuncture for adolescents with mild-to-moderate myopia: study protocol for a randomized controlled trial

    Myopia is a public health problem worldwide and its incidence increases with age. The use of acupuncture to treat myopia is a common practice in China, however, the use of acupuncture to treat myopia is disput...

    Yan Wang, Yun-xian Gao, Qi Sun, Qian Bu, **g Shi, Ya-ni Zhang, Qin Xu, Yan Ji… in Trials (2014)

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  6. No Access

    Article

    Novel ether-functional spiro-tetronic acid derivatives: molecule design, convenient synthesis and biological evaluation

    A novel series of ether functionalization of spiro-tetronic acid derivatives have been designed and conveniently synthesized via three steps, including esterification, one-pot heterocyclization, and etherifica...

    Shaoyong Ke, Zhigang Zhang, Ya-Ni Zhang, Liqiao Shi… in Research on Chemical Intermediates (2012)

  7. No Access

    Article

    Structural diversity-guided convenient construction of functionalized 4H-1,3,4-oxadiazin-5(6H)-one derivatives

    A molecular diversity-oriented convenient access to multi-substituted 1,3,4-oxadiazinone scaffolds via four different methods from substituted benzoic acid derivatives is described. The target molecules have b...

    Shaoyong Ke, Kaimei Wang, Zhigang Zhang, Ya-Ni Zhang… in Research on Chemical Intermediates (2012)