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Article
A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression
Human-specific insertions play important roles in human phenotypes and diseases. Here we reported a 446-bp insertion (Insert-446) in intron 11 of the TBC1D8B gene, located on chromosome X, and traced its origin t...
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Article
Open AccessIdentification of fetal cardiac anatomy and hemodynamics: a novel enhanced screening protocol
Prenatal cardiac screening is of great importance as it contributes to appropriate neonatal management and helps parents to make a decision regarding their pregnancy. The aim of our study was to evaluate the e...
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Article
Plutella xylostella granulovirus late gene promoter activity in the context of the Autographa californica multiple nucleopolyhedrovirus genome
Within Baculoviridae, little is known about the molecular mechanisms of replication in betabaculoviruses, despite extensive studies in alphabaculoviruses. In this study, the promoters of nine late genes of the be...
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Article
Iterative learning control for discrete parabolic distributed parameter systems
In this paper, iterative learning control (ILC) technique is applied to a class of discrete parabolic distributed parameter systems described by partial difference equations. A P-type learning control law is e...
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Article
Fabrication, characterization, and biocompatibility of ethyl cellulose/carbonated hydroxyapatite composite coatings on Ti6Al4V
In order to improve the biocompatibility of metallic implants, bioactive components are often used as coatings so that a real bond with the surrounding bone tissue can be formed. We prepared ethyl cellulose/c...
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Article
Open AccessRight atrial pressure alterations during echocardiography-guided-catheterization predict tricuspid valvular impairment: a novel method for the creation of a rabbit model of Staphylococcus aureus endocarditis
We previously reported the use of a catheter system to damage the tricuspid valve and create infectious endocarditis (IE) in an animal model. The current study aims to create a faint IE model suitable for anti...
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Article
Open AccessParasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei
Malaria and schistosomiasis are endemic and co-exist in the same geographic areas, even co-infecting the same host. Previous studies have reported that concomitant infection with Schistosoma japonicum could offer...
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Article
Pervaporation separation of dimethyl carbonate/methanol binary mixtures with poly(vinyl alcohol)-perfluorslulfonic acid/poly(acrylonitrile) hollow fiber composite membranes
Using poly(vinyl alcohol) (PVA) and perfluorslulfonic acid (PFSA) as coating materials, poly(acrylonitrile) (PAN) hollow fiber ultrafiltration membrane as substrate, PVA-PFSA/PAN composite membranes were fabri...
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Article
Open AccessPre-existing Schistosoma japonicum infection alters the immune response to Plasmodium berghei infection in C57BL/6 mice
Since helminths and malaria parasites are often co-endemic, it is important to clarify the immunoregulatory mechanism that occurs during the process of co-infection. A previous study confirmed that dendritic c...
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Article
Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
Accumulating evidence has demonstrated that myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells, play an important role in the subversion, inhibition, and downregulation of the immune...
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Article
Open AccessPrenatal diagnosis of fetal unilateral lung agenesis complicated with cardiac malposition
Fetal unilateral lung agenesis, complicated with cardiac shifting, is a rare anomaly, the diagnosis of which remains a challenge for many sonographers in routine screening programs. The present study describes...
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Article
Open AccessA rabbit model of right-sided Staphylococcus aureus endocarditis created with echocardiographic guidance
The most widely used experimental models of infective endocarditis (IE) are the rabbit and rat models, in which cardiac valve lesions are induced by a polyethylene catheter introduced into the left ventricle t...
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Article
Tolerability, pharmacokinetics and pharmacodynamics of CMAB001, an anti-CD11a antibody, in Chinese healthy volunteers and psoriatic patients
To evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and primary tolerability of an anti-CD11a monoclonal antibody (CMAB001) in Chinese healthy volunteers and psoriatic patients.
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Article
The dual role of osteopontin in acetaminophen hepatotoxicity
Osteopontin (OPN), a multifunctional protein, has been reported to be protoxicant in acetaminophen hepatotoxicity. In this study, the mechanisms underlying the detrimental role of OPN in acetaminophen toxicity...
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Article
Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis
To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA).
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Article
Pharmacokinetic and pharmacodynamic study of LFA3Ig fusion protein in healthy volunteers and patients with psoriasis
To evaluate the pharmacokinetics (PK) and pharmacodynamics of the LFA3Ig fusion protein (LFA3IgFP) in healthy volunteers and patients with chronic plaque psoriasis.
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Chapter and Conference Paper
Drawing Undirected Graphs with Genetic Algorithms
This paper proposes an improved genetic algorithm for producing aesthetically pleasing drawings of general undirected graphs. Previous undirected graph drawing algorithms draw large cycles with no chords as co...
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Article
Apoptosis in oncology
Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveilla...
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Article
A modified specimen for evaluating the mixed mode fracture toughness of adhesives
This article introduces a specimen geometry that allows the separation of fracture energy release rates G I and G II in adhesively joined beams made of disparate materials. The...
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Article
Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies
Antitumor immune responses are mediated primarily by T cells1. Downregulation of the major histocompatiblity complex (MHC) and the molecules that costimulate the immune response is associated with defective signa...
