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    Article

    A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

    Human-specific insertions play important roles in human phenotypes and diseases. Here we reported a 446-bp insertion (Insert-446) in intron 11 of the TBC1D8B gene, located on chromosome X, and traced its origin t...

    Hui Zhao, Lin-Lin Liu, Jian Sun, Lian **, Hai-Bing **e… in Science China Life Sciences (2024)

  2. Article

    Tolerability, pharmacokinetics and pharmacodynamics of CMAB001, an anti-CD11a antibody, in Chinese healthy volunteers and psoriatic patients

    To evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and primary tolerability of an anti-CD11a monoclonal antibody (CMAB001) in Chinese healthy volunteers and psoriatic patients.

    ** Li, **g Li, Heng Yan, Bo Zhou, Bo-hua Li… in Acta Pharmacologica Sinica (2012)

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  3. Article

    Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis

    To evaluate single-dose and multiple-dose pharmacokinetics of cytotoxic T-lymphocyte-associated antigen 4 fusion protein (CTLA4Ig) in healthy volunteers and patients with rheumatoid arthritis (RA).

    Ying Ma, Bi-rong Lin, Bei Lin, Sheng Hou, Wei-zhu Qian… in Acta Pharmacologica Sinica (2009)

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  4. Article

    Pharmacokinetic and pharmacodynamic study of LFA3Ig fusion protein in healthy volunteers and patients with psoriasis

    To evaluate the pharmacokinetics (PK) and pharmacodynamics of the LFA3Ig fusion protein (LFA3IgFP) in healthy volunteers and patients with chronic plaque psoriasis.

    ** Li, **g Li, Heng Yan, Sheng Hou, Wei-zhu Qian… in Acta Pharmacologica Sinica (2008)

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