-
Article
The influence of season and air temperature on water intake by food groups in a sample of free-living Japanese adults
To examine the influence of season and climate (air temperature and humidity) on water intake by the food group in a sample of free-living Japanese adults.
-
Article
Processing of high-molecular-weight form adrenocorticotropin in human adrenocorticotropin-secreting tumor cell line (DMS-79) after transfection of prohormone convertase 1/3 gene
Ectopic ACTH-producing tumors preferentially secrete biologically inactive ACTH precursors and ACTH-related fragments. DMS-79 is known to secrete unprocessed high-molecular-weight (HMW) form ACTH. To determine...
-
Chapter
McLeod Syndrome: A Perspective from Japanese Blood Centers
McLeod phenotype is one of the rare blood cell types, defined as those that occur at a frequency of 1:1,000 or less. We have screened donors for rare cells since 1987 using mouse monoclonal antibodies (MAbs). ...
-
Article
Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer
Interleukin-12 (IL-12) is a potent antitumoral cytokine, but high doses are toxic. Herein, we demonstrate that combinational transduction of IL-12 and CC-chemokine ligand-27 (CCL27) genes into pre-existing mur...
-
Article
Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector
Our goal in the present study was to evaluate antitumor effects and frequency of tumor-infiltrating immune cells upon intratumoral injection of RGD fiber-mutant adenoviral vector (AdRGD) encoding the chemokine...
-
Article
Antibacterial and antipeptide antibodies in Japanese and Finnish patients with rheumatoid arthritis
It has been suggested that Proteus infection may be involved in the pathogenesis of rheumatoid arthritis (RA). Bacterial and peptide immune responses in patients with RA and other control subjects were investigat...
-
Article
Behçet's disease and sacroiliitis in a child
We describe the case of a Japanese girl who suffered from both Behçet's disease (BD) and bilateral sacroiliitis. This patient was diagnosed with BD at 8 years of age, and began to complain of buttock pain whe...
-
Article
Surface modification of fine colloidal silica with copolymer silane-coupling agents composed of maleic anhydride
The reactivity of copolymer silane composed of maleic anhydride in the modification of fine colloidal silica was studied. The reaction of colloidal silica of 10 and 45-nm diameter with trimethoxysilyl-termina...
-
Article
Intelligent yeast strains with the ability to self-monitor the concentrations of intra- and extracellular phosphate or ammonium ion by emission of fluorescence from the cell surface
Saccharomyces cerevisiae strains that respond to environmental changes and transmit the information by emission of fluorescence from the cell surface were constructed. The technique of cell surface engineering ...
-
Article
Direct demonstration of humorally mediated inhibition of the transcription of phosphate transporter in XLH patients
-
Article
Sociodemographic factors and failure of hip arthroplasty
To identify the sociodemographic and lifestyle factors related to development of aseptic loosening after a cemented total hip arthroplasty (THA), 151 consecutive primary THAs performed at a single hospital in ...
-
Article
Locking of metacarpophalangeal joints in a patient with acromegaly
A 39-year-old man with acromegaly exhibited locking of metacarpophalangeal (MCP) joints of both index fingers. Large osteophytes were found at the metacarpal heads by radiography and computerized tomography (C...
-
Article
Characterization of a biosurfactant, mannosylerythritol lipid produced from Candida sp. SY16
One yeast strain, SY16, was selected as a potential producer of a biosurfactant, and identified as a Candida species. A biosurfactant produced from Candida sp. SY16 was purified and confirmed to be a glycolipid....
-
Article
The STR polymorphisms in intron 8 may provide information about the molecular evolution of RH haplotypes
We identified simple-sequence repeat polymorphisms in intron 8 of the RHD and RHCE genes, both of which contained the 5-bp repeat unit (AAAAT)n. We analyzed the polymorphisms of this short tandem repeat (STR) in...
-
Article
Intramedullary fibular graft for supracondylar fracture of the femur following total knee arthroplasty
We describe a successful treatment, intramedullary fibular grafting, for a patient with a supracondylar fracture of the femur following total knee arthroplasty in which the fracture region was comminuted and a...
-
Article
Cathepsin B in gingival crevicular fluid of adult periodontitis patients: Identification by immunological and enzymological methods
Cathepsin B (EC 3.4.22.1), a typical lysosomal cysteine proteinase was identified immunologically with anti-human cathepsin B antibody in inflammatory exudate, gingival crevicular fluid (GCF) of adult periodon...
-
Article
Molecular Mimicry: The Geographical Distribution of Immune Responses to Klebsiella in Ankylosing Spondylitis and its Relevance to Therapy
The discovery that HLA- B27 is linked to ankylosing spondylitis (AS) and HLA- DR1/DR4 to rheumatoid arthritis (RA) has provided new approaches to the study of the possible causation of these diseases. Several ...
-
Article
Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey
The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the Rhesus monkey brain were investigated by positron emission tomography (PET) with the ...
-
Article
Expression of Saccharomyces adenylate kinase gene in Candida boidinii under the regulation of its alcohol oxidase promoter
The methylotrophic yeast, Candida boidinii, was investigated as a new efficient host for heterologous gene expression. The Saccharomyces cerevisiae adenylate kinase gene (ADK1) was used as the first example for h...
-
Chapter
GP130 in Human Myeloma/Plasmacytoma
Interleukin 6 (IL-6) is a potent growth factor for human myeloma/plasmacytoma cells (Kawano et al. 1988, Klein et al. 1989) The evidences that 1) myeloma cells produce IL-6 and express IL-6 receptor (IL-6R), 2...
