-
Article
Numerical Research of High-Voltage Conductors: Electric Field Characteristics in Ice-Covered Spaces
The icing of overhead high-voltage transmission lines not only caused accidents such as line dance down pole and flashover, but also lead to abnormal field strength on the line surface and distortion of electr...
-
Article
Open AccessParathyroid hormone (1–34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats
Facet joint degeneration (FJD) is a major cause of low back pain. Parathyroid hormone (PTH) (1–34) is commonly used to treat osteoporosis. However, little is known about its effects on FJD induced by estrogen ...
-
Article
Open AccessAn adeno-associated virus variant enabling efficient ocular-directed gene delivery across species
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administere...
-
Article
ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
Gastric carcinoma (GC) is regarded as one of the deadliest cancer characterized by diversity and haste metastasis and suffers limited understanding of the spatial variation between primary and metastatic GC tu...
-
Article
A remark on a weighted version of Suita conjecture for higher derivatives
In this article, we consider the set of points for the holding of the equality in a weighted version of Suita conjecture for higher derivatives, and give relations between the set and the integer valued points...
-
Article
Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy
Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines, resulting in undesirable drug delivery efficacy and therapeutic outcomes....
-
Article
HSK3486 Inhibits Colorectal Cancer Growth by Promoting Oxidative Stress and ATPase Inhibitory Factor 1 Activation
HSK3486 (ciprofol), a new candidate drug similar to propofol, exerts sedative and hypnotic effects through gamma-aminobutyric acid type A receptors; however, its potential role in colorectal cancer is currentl...
-
Article
Open AccessTMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC pluripotency remains unexplored. Transmembrane protein 120B (TMEM120B) is a newly discov...
-
Article
New insights into the effect of pyrolysis temperature on the spectroscopy properties of dissolved organic matter in manure-based biochar
Dissolved organic matter (DOM) derived from biochar takes a crucial role in transport and bioavailability toward contaminants; hence, it is undeniable that a thorough analysis of its properties is important. S...
-
Article
Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion. Each amino acid is coupled to a designated peptidyl carrier protein (PCP) through tw...
-
Chapter and Conference Paper
Research Status and Progress of Foam Drainage-Gas Recovery Technology in Shale Gas Wells
Shale gas is an important unconventional energy. Because of its special geological structure and complex well depth structure, it is difficult to exploit and will produce wellbore fluid accumulation in the pro...
-
Chapter and Conference Paper
Experimental Study on Hydraulic Fracture Propagation Mechanism of Water Injection Propagation in Super Deep Fracture-Cavity Carbonate Reservoir
The super deep fracture-cavity carbonate reservoir in Tarim Basin has copious amounts of oil and gas, in which karst cave is the main reservoir space. It is necessary to communicate with karst cave through hyd...
-
Chapter and Conference Paper
Rapid Recovery of Voltage Sag in Distribution Network Based on Dq Transformation
This paper proposes a real-time voltage compensation method based on dq transformation by simulating three-phase voltage. With A, B and C phases as reference, the phase locking method of second order generaliz...
-
Chapter and Conference Paper
Application of Virtual Simulation Technology in Experimental Teaching of Emergency Nursing
The application of virtual simulation technology in emergency nursing experimental teaching is to simulate the real world situation, which can be used to practice and improve skills. The advantage is that it c...
-
Chapter and Conference Paper
Study on Screening and Performance Evaluation Technology of Salt-Tolerant Foaming Agent
Foam drainage gas recovery technology is one of the most important technologies in drainage and gas production of shale gas wells. The effect of foam drainage which the main component of foaming agent is surfa...
-
Chapter and Conference Paper
Application Study of Virtual Reality Technology Assisted Training in College Physical Education
With the sustainable development and progress of social economy, the level of science and information technology is also constantly improved. VR technology arises at the historic moment in this era environment...
-
Article
Open AccessRegulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microen...
-
Article
Open AccessAtg7 senses ATP levels and regulates AKT1-PDCD4 phosphorylation-ubiquitination axis to promote survival during metabolic stress
We report that autophagy-related gene 7 (ATG7) modulates p53 activity to regulate cell cycle and survival during metabolic stress, and that indicates Atg7 is functionally involved in cellular homeostasis in au...
-
Article
Open AccessAdded value of regional 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in malignant ascites with unknown primary origin
Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in dia...
-
Article
Experimental study on multi-scale damage and deterioration mechanism of carbonaceous slate under freeze-thaw cycles
This study investigates the macro and micro multi-scale damage effects of freeze-thaw cycles and confining pressure on slate tunnel rock in cold regions. Herein, carbonaceous slate excavated from a tunnel unde...
