-
Article
Open AccessCorrection to: Construction of cell factory capable of efficiently converting l‑tryptophan into 5‑hydroxytryptamine
-
Article
Open AccessLong noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer
Aromatase inhibition is an efficient endocrine therapy to block ectopic estrogen production for postmenopausal estrogen receptor (ER)-positive breast cancer patients, but many develop resistance. Here, we show...
-
Article
Open AccessConstruction of cell factory capable of efficiently converting l-tryptophan into 5-hydroxytryptamine
l-Tryptophan (l-Trp) derivatives such as 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT), N-Acetyl-5-hydroxytryptamine and melatonin are important molecules with pharmaceutical interest. Among, 5-HT is...
-
Article
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer
Reduced infiltration of anti-tumor lymphocytes remains a major cause of tumor immune evasion and is correlated with poor cancer survival. Here, we found that upregulation of regulator of G protein signaling (R...
-
Article
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer
Although chemotherapy can stimulate antitumor immunity by inducing interferon (IFN) response, the functional role of tumor-associated macrophages in this scenario remains unclear. Here, we found that IFN-activ...
-
Article
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25
Neutrophil extracellular traps (NETs), which consist of chromatin DNA filaments coated with granule proteins, are released by neutrophils to trap microorganisms1–3. Recent studies have suggested that the DNA comp...
-
Article
Turning foes to friends: targeting cancer-associated fibroblasts
Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance. Among all the stromal cells t...
-
Article
Open AccessMammary stem cells: angels or demons in mammary gland?
A highly dynamic development process exits within the epithelia of mammary gland, featuring morphogenetic variation during puberty, pregnancy, lactation, and regression. The identification of mammary stem cell...
-
Chapter
The Dawning of Translational Breast Cancer: From Bench to Bedside
Breast cancer is one of the world’s leading causes of death in women. Although tumor initiation and progression are predominantly driven by somatic or acquired (epi) genetic alterations that govern signaling a...
-
Chapter
Noncoding RNAs: New Players in Cancers
The world of noncoding RNAs (ncRNAs) has gained widespread attention in recent years due to their novel and crucial potency of biological regulation. Noncoding RNAs play essential regulatory roles in a broad r...
