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Chapter and Conference Paper
Automatic Control Algorithm for Cardiac Output Regulation of the Total Artificial Heart (TAH)
An automatic control algorithm for the moving-actuator type total artificial heart (TAH) was developed based on motor current waveform analysis. Instead of using relatively complicated analysis of the instanta...
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Chapter and Conference Paper
Orthotopic Implantation of the Tether-Free Moving-Actuator Type Total Artificial Heart in Sheep
An electromechanical total artificial heart (TAH) was developed. Its fitting trials were performed with computer simulations, and we orthotopically implanted it in 60- to 70-kg sheep in tether-free operations....
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Chapter and Conference Paper
Implantable Controller with Fault Tolerance for the Moving-Actuator Total Artificial Heart (TAH): Use of a Dual Board
An implantable dual controller with fault tolerance for a total artificial heart (TAH) was developed and evaluated by in vivo studies. The TAH controller has problems normally caused by driving inductive loads...
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Chapter and Conference Paper
Automatic Regulation of Output of an Electrohydraulic Left Ventricular Assist Device Using the Polymer Bellows Water Pressure and Motor Current
An electrohydraulically driven left ventricular assist device (LVAD) has been developed in our laboratory. Over years of in vitro and in vivo testing, a “suction” problem has been pointed out as one of the maj...
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Chapter and Conference Paper
Further Development of the Moving-Actuator Type Total Artificial Heart
The electromechanical total artificial heart (TAH) developed at Seoul National University Hospital was verified as acceptable for human implantation through several successful animal experiments. In the last t...
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Article
MMA/MPEOMA/VSA copolymer as a novel blood-compatible material: ex vivo platelet adhesion study
MMA/MPEOMA/VSA copolymers with both pendant polyethylene oxide (PEO) side chains and negatively chargeable side groups were synthesized by random copolymerization of methyl methacrylate (MMA), methoxy PEO mono...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, we isolated two new isoflavonol glycosides, genistein 7-α-L-6-deoxy-talopyranoside (talosin A) and genistein 4′,7-di-α-L-6-...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides with potent antifungal activity, talosins A and B, were isolated from the culture broth of K...
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Article
Atromentin and Leucomelone, the First Inhibitors Specific to Enoyl-ACP Reductase (FabK) of Streptococcus pneumoniae
Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were ...
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Article
Verticillin G, a New Antibacterial Compound from Bionectra byssicola
A new epidithiodioxopiperazine compound named verticillin G along with the known compound verticillin D has been isolated from the mycelium of liquid fermentation cultures of a fungal strain Bionectra byssicola F...
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Article
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structur...
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Article
Macrolactin S, a New Antibacterial Agent with Fab G-inhibitory Activity from Bacillus sp. AT28
In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound macrolactin B, has been isolated from the mycelium of li...
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Article
Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina
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Article
Isolation of a Calcium-binding Substance from Anchovy
Dried anchovy (Engraulis japonica) was extracted using hot water and filtered with a YM-3 membrane to isolate a calcium binding substance. The membrane filtered solution was fractionated using gel permeation chro...
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Article
Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611
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Article
Verrulactones D and E with unprecedented skeletons, new inhibitors of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375
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Article
AN483, a new anti-MRSA compound from Streptomyces sp.
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Article
Open AccessImprovement of the pharmacological activity of menthol via enzymatic β-anomer-selective glycosylation
Menthol has a considerable cooling effect, but the use range of menthol is limited because of its extremely low solubility in water and inherent flavor. (−)-Menthol β-glucoside was determined to be more solubl...
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Article
Enzymatic synthesis of avermectin B1a glycosides for the effective prevention of the pine wood nematode Bursaphelenchus xylophilus
Avermectin produced by Streptomyces avermitilis is an anti-nematodal agent against the pine wood nematode Bursaphelenchus xylophilus. However, its potential usage is limited by its poor water solubility. For this...
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Article
Open AccessTerrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP
To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspe...
