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Fluorogenic DNA sequencing in PDMS microreactors

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  1. Article

    Open Access

    Integration of spatial and single-cell data across modalities with weakly linked features

    Although single-cell and spatial sequencing methods enable simultaneous measurement of more than one biological modality, no technology can capture all modalities within the same cell. For current data integra...

    Shuxiao Chen, Bokai Zhu, Sijia Huang, John W. Hickey, Kevin Z. Lin… in Nature Biotechnology (2023)

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  2. Article

    Open Access

    Multicenter integrated analysis of noncoding CRISPRi screens

    The ENCODE Consortium’s efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to ...

    David Yao, Josh Tycko, ** Woo Oh, Lexi R. Bounds, Sager J. Gosai… in Nature Methods (2024)

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  3. Article

    Open Access

    Systematic benchmarking of single-cell ATAC-sequencing protocols

    Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity. However, an exploration of syst...

    Florian V. De Rop, Gert Hulselmans, Chris Flerin, Paula Soler-Vila… in Nature Biotechnology (2024)

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