-
Article
Open AccessMulticenter integrated analysis of noncoding CRISPRi screens
The ENCODE Consortium’s efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to ...
-
Article
Author Correction: Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH
-
Article
Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR–FlowFISH
Effective interpretation of genome function and genetic variation requires a shift from epigenetic map** of cis-regulatory elements (CREs) to characterization of endogenous function. We developed hybridization ...
-
Article
Publisher Correction: Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
In the version of this article initially published online, the fifth author’s name was given as Alexander Amlie-Wolf. The correct name is Alexandre Amlie-Wolf. The error has been corrected in the print, PDF an...
-
Article
Open AccessDysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease
Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and...
-
Chapter
Genome-Wide Approaches for RNA Structure Probing
RNA molecules of all types fold into complex secondary and tertiary structures that are important for their function and regulation. Structural and catalytic RNAs such as ribosomal RNA (rRNA) and transfer RNA ...
