-
Article
Open AccessMulticenter integrated analysis of noncoding CRISPRi screens
The ENCODE Consortium’s efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to ...
-
Article
Open AccessAssembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
The assembly of cortical circuits involves the generation and migration of interneurons from the ventral to the dorsal forebrain1–3, which has been challenging to study at inaccessible stages of late gestation an...
-
Article
Preface: Special Issue on Optimization, Financial Engineering, Risk and Operations Management
-
Article
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis
Monoclonal antibody therapies targeting tumour antigens drive cancer cell elimination in large part by triggering macrophage phagocytosis of cancer cells1–7. However, cancer cells evade phagocytosis using mechani...
-
Article
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
Cancer genomics studies have identified thousands of putative cancer driver genes1. Development of high-throughput and accurate models to define the functions of these genes is a major challenge. Here we devised ...
-
Article
Structural controls on granitoid-hosted gold mineralization and paleostress history of the Edikan gold deposits, Kumasi Basin, southwestern Ghana
The > 9 Moz total aggregate gold endowment at the Edikan mine, Kumasi Basin, Ghana, is contained within a cluster of orogenic gold deposits located along the Akropong fault zone. The granitoid-hosted orebodies...
-
Article
Open AccessMitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory elements in the non-coding genome, but off-target effects in these experiments have not been systematically evaluated...
-
Article
Open AccessInflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis
Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to dete...
-
Article
Editorial introduction
-
Chapter
The Viscoplasticity Theory Based on Overstress Applied to Ratchetting and Cyclic Hardening
The cyclic neutral version of the theory of viscoplasticity based on over-stress (VBO) is introduced and applied to predict the zero-to-tension ratchetting behavior of a Tialloy at room temperature. The experi...
