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Article
The Relationship between Temperature and Calcium in Acute Cell Damage after Exposure to Radiofrequency or Thermal Energy in Isolated Neonatal and Adult Rabbit Cardiac Myocytes
Radiofrequency (RF) ablation is a nonsurgical technique using catheter-directed RF energy for treating cardiac arrhythmias in children and adults. Previous reports have suggested that sequestration of calcium(Ca2...
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Article
Caffeine-Induced Contractions in Develo** Rabbit Heart
Mature myocardium utilizes calcium released by the sarcoplasmic reticulum(SR) for cell contraction. Transient exposure of mature myocytes to caffeine is known to directly trigger Ca2+ release from the SR. In cont...
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Article
DEVELOPMENTAL CHANGES IN SARCOPLASMIC RETICULUM Ca2+-ATPase PROTEIN EXPRESSION IN RABBIT HEARTS. • 132
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Article
AGE-RELATED CHANGES IN THE TIME COURSE OF THE CA2+ TRANSIENT IN CONTRACTING RABBIT MYOCYTES. † 225
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Article
ATP-Sensitive Potassium Channels in Neonatal and Adult Rabbit Ventricular Myocytes
ABSTRACT: The properties of the ATP-sensitive potassium (KATP) current were studied in freshly isolated rabbit ventricular myocytes using the patch clamp technique. Removing ATP from the bath (intracellular) solu...
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Article
Calcium Current Measurements in Acutely Isolated Neonatal Cardiac Myocytes
ABSTRACT: Action potentials and voltage clamp-induced ionic currents were recorded in acutely isolated neonatal rabbit cardiac myocytes using the whole-cell voltage clamp technique. Time- and voltage-dependent Ca
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Article
The Biphasic Effect of Amrinone on Tension Development in Newborn Mammalian Myocardium
ABSTRACT: The effect of the bipyridine compound, amrinone, on tension generation in neonatal and adult myocardium was studied over the concentration range 30-500 μg/mL. Increasing concentrations of amrinone ca...
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Article
A Diminished Role for the Sarcoplasmic Reticulum in Newborn Myocardial Contraction: Effects of Ryanodine
ABSTRACT: Ryanodine, known to reduce Ca2+ release from the sarcoplasmic reticulum (SR), was used in conjunction with the single sucrose gap voltage clamp technique to study excitation-contraction coupling in papi...
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Article
Excitation-Contraction Coupling in Develo** Mammalian Myocardium: Evidence from Voltage Clamp Studies
ABSTRACT: The single sucrose gap voltage clamp technique was used to study excitation-contraction coupling processes in right ventricular papillary muscles from New Zealand White rabbits at various stages of d...
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Article
NEWER CARDIOTONIC AGENTS – BENEFICIAL EFFECTS ON NEWBORN MYOCARDIUM
Previous data has suggested a deleterious action of Amrinone (Am) on newborn (NB) myocardium. An investigation of the relationship between dose, age, and contractility has been undertaken using isolated right ...
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Article
Proceedings of National Heart, Lung, and Blood Institute Pediatric Cardiology Workshop: Pulmonary Hypertension
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Chapter and Conference Paper
Clinical Problems of the Perinatal Circulation: Developmental Aspects of Myocardial Function
The newborn heart has a reduced ability, when compared to the heart of the older child or adult, to call upon a functional reserve capacity to adapt to the stress of hypoxia, anoxia, or ischemia.
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Chapter and Conference Paper
Systemic Venous and Pulmonary Arterial Flow Patterns after Fontan’s Procedure for Tricuspid Atresia or Single Ventricle
Despite increasing use of the Fontan or modified Fontan repairs, the comparative hemodynamic efficacies of different types of connections are unresolved. Accordingly, we undertook a prospective study designed ...
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Article
112 THE AGE DEPENDENCY OF MYOCARDIAL EXCITATION CONTRACTION COUPLING
Mechanisms of excitation-contraction coupling in mammalian ventricle may be age dependent. Accordingly, sucrose gap voltage clamp techniques were developed to control membrane potential while simultaneously me...
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Article
Inotropic Effects of Prostaglandin D2 and E1 on the Newborn Rabbit Heart
ABSTRACT: This study determines the inotropic effects of prostaglandin D2 (PGD2) and prostaglandin E1 (PGE1) in the isolated, arterial perfused newborn (NB) and adult (A) rabbit heart.
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Article
THE INOTROPIC EFFECT OF PROSTAGLANDIN (PG)E1 AND PGD2 IN THE NEWBORN RABBIT HEART
The purpose of this study was to determine the effects of PGE1 and PGD2 on mechanical function in the develo** heart. The study was performed in the isolated, arterially perfused heart preparation of the newbor...
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Article
The Vasoactivity of the Fetal Lamb Ductus Arteriosus Studied in Utero
Summary: The ductus arteriosus of the undisturbed fetal lamb was studied chronically by techniques that allowed direct serial measurements of the calibre of the fetal channel. When the direct actions were stud...
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Article
Complex cyanotic congenital heart disease correctable with an intra-atrial baffle
The clinical, angiocardiographic, and surgical findings in a cyanotic child with dextrocardia, L-loop, laterally inverted but otherwise normally related great arteries, and situs ambiguus are described and com...
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Article
Maturation of Energy Metabolism in the Lamb: Changes in Myosin ATPase and Creatine Kinase Activities
Summary: Studies have been carried out to assess maturation of myofibrillar and mitochondrial proteins in fetal (113 to 140 days gestation), neonatal (30 min to 21 days postpartum), and adult sheep hearts.Ca++-ac...
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Article
1424 THE RELATIONSHIP BETWEEN TOTAL FLUID ADMINISTRATION AND INDOMETHACIN (I) DOSE NEEDED TO CLOSE THE DUCTUS ARTERIOSUS (DA)
The effect of fluid administration upon pharmacological closure of the DA by intravenous I, was evaluated in a prospective randomized study of 23 preterm infants, less than age 7 days, whose birth weight varie...
