-
Article
Open AccessThe role of discrimination in the relation between COVID-19 sequelae, psychological distress, and work impairment in COVID-19 survivors
Perceived discrimination and work impairment are commonly observed in COVID-19 survivors, but their relationship has not been well understood. We aimed to evaluate the role of discrimination in the development...
-
Article
Correction to: Growth references for Japanese individuals with Noonan syndrome
-
Article
Comparison between human liver microsomes and the fungus Cunninghamella elegans for biotransformation of the synthetic cannabinoid JWH-424 having a bromo-naphthyl moiety analysed by high-resolution mass spectrometry
JWH-424, (8-bromo-1-naphthyl)(1-pentyl-1H-indol-3-yl)methanone, is a synthetic cannabinoid, which is a brominated analogue of JWH-018, one of the best-known synthetic cannabinoids. Despite the structural similari...
-
Article
Outcomes of hypertrophic cardiomyopathy in Japanese children: a retrospective cohort study
There has been no multicenter study on the prognosis of pediatric hypertrophic cardiomyopathy (HCM) in Japan. Therefore, we conducted a retrospective multicenter observational study on the long-term survival r...
-
Article
Open AccessLong COVID occurrence in COVID-19 survivors
This cross-sectional study aimed to investigate the post-acute consequences of COVID-19. We conducted a self-administered questionnaire survey on sequelae, psychological distress (K6), impairments in work perf...
-
Article
Correction to: Outcomes of idiopathic pulmonary arterial hypertension in Japanese children: a retrospective cohort study
A correction to this paper has been published: https://doi.org/10.1007/s00380-021-01882-3
-
Article
Outcomes of idiopathic pulmonary arterial hypertension in Japanese children: a retrospective cohort study
Recently, targeted therapy has been developed for idiopathic pulmonary arterial hypertension (IPAH). Studies evaluating the prognosis of IPAH have been conducted in adults. However, there is no nationwide surv...
-
Article
Mid- to long-term surgical outcomes of partial anomalous pulmonary venous connection
To investigate mid- to long-term morbidity and mortality after the repair of partial anomalous pulmonary venous connections (PAPVCs).
-
Chapter and Conference Paper
Establishment of Induced Pluripotent Stem Cells from Immortalized B Cell Lines and Their Differentiation into Cardiomyocytes
Collection of peripheral blood from many patients over a long period of time has resulted in the establishment of a library composed of more than 4400 immortalized B cell lines, which have been used to identif...
-
Chapter and Conference Paper
A Genetic Analysis for Patients with Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a lethal disease [1]. Although mutations in BMPR2 and other genes have been reported, the genetic causes in large numbers of patients, especially with sporadic PAH, remain...
-
Chapter and Conference Paper
Dilatation of the Ductus Arteriosus by Diazoxide in Fetal and Neonatal Rats
We previously reported that ATP-sensitive potassium (KATP) channels regulate ductal constriction in response to oxygen [1]. Diazoxide is a KATP channel opener while the usefulness of diazoxide for hyperinsulinemi...
-
Chapter and Conference Paper
Involvement of CXCR4 and Stem Cells in a Rat Model of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome. C-X-C chemokine receptor type 4 (CXCR4) is known to be expressed in cancer and stem/progenitor cells. In the present study, PAH wa...
-
Chapter and Conference Paper
Perspective for Part II
Pulmonary blood flow increases gradually during fetal life, and dramatic changes in the pulmonary circulation occur from the fetus to newborn, including decrease in pulmonary arterial resistance, increase in p...
-
Chapter and Conference Paper
The Different c-kit Expression in Human Induced Pluripotent Stem (iPS) Cells Between With Feeder Cells and Without Feeder Cells
c-kit is a stem cell factor (SCF) receptor and is known to be expressed in hematopoietic stem cells, prostate stem cells, mast cells, and melanocytes. Since c-kit was reportedly expressed in cardiac stem cells...
-
Chapter and Conference Paper
Establishment of an In Vitro LQT3 model Using Induced Pluripotent Stem Cells from LQT3 Patient-Derived Cardiomyocytes
Cardiomyocytes derived from induced pluripotent stem cells (iPSC) are used to evaluate the function and risk factors of genetic variations linked to congenital and adult heart diseases in human beings. Our pur...
-
Chapter and Conference Paper
Perspective for Part III
The ductus arteriosus (DA) is open before birth and normally closes after birth. The unique anatomy and normal and abnormal behavior of the DA are discussed by Gittenberger, Shelton, and Sterren in this chapter.
-
Chapter and Conference Paper
Constriction of the Ductus Arteriosus with KATP Channel Inhibitors
The cause of fetal death by sulfonylureas (SUs), used for diabetes in pregnancy in the early 1960s, remained unsolved for decades. In 1993, Nakanishi discovered constriction of ductus arteriosus (DA) strips in...
-
Article
Open AccessSilibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia
C-X-C chemokine receptor type 4 (CXCR4) may be involved in the development of pulmonary arterial hypertension (PAH). CXCR4 inhibitor AMD3100 was described to have a positive effect on the prevention of pulmona...
-
Article
Open AccessGenome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage
Sparassis crispa (Hanabiratake) is a widely used medicinal mushroom in traditional Chinese medicine because it contains materials with pharmacological activity. Here, we report its 39.0-Mb genome, encoding 13,157...
-
Article
Open AccessGenetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are genetically and phenotypically heterogeneous. Cardiac function is improved after treatment in some cardiomyopathy patients, but little is ...
