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Article
DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway
Recurrent breast cancer presents significant challenges with aggressive phenotypes and treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report that murine recurrent breast tumo...
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Article
Open AccessZinc transporter ZIP7 is a novel determinant of ferroptosis
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages. The name of ferroptosis indicates that the ...
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Article
RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence
The molecular and genetic basis of tumor recurrence is complex and poorly understood. RIPK3 is a key effector in programmed necrotic cell death and, therefore, its expression is frequently suppressed in primar...
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Article
MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective accumulation and degradation of (p)ppGpp by RelA and SpoT homo...
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Article
Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been implicated in various human ...
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Article
Open AccessQuantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes
Changes in the deformability of red blood cells can reveal a range of pathologies. For example, cells which have been stored for transfusion are known to exhibit progressively impaired deformability. Thus, thi...
