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Article
Open AccessDownregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis
Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with s...
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Article
Weakly supervised video anomaly detection based on spatial–temporal feature fusion enhancement
When an abnormal event occurs, the features of the video will gradually change in the temporal sequences. Since the abnormal event is a continuous process, the abnormal features should have a continuous promin...
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Article
Construction of hierarchical SnO2@SnS2 nanostructures on carbon cloth as advanced microwave absorbers
Carbon cloth-based electromagnetic wave (EMW) absorbing materials have been widely studied due to their advantages of light weight, flexibility and high strength. At present, researchers widely use chemical in...
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Article
Open AccessOral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus
Children of mothers with gestational diabetes mellitus (GDM) are more prone to acquire type 2 diabetes and obesity as adults. Due to this link, early intervention strategies that alter the gut microbiome may b...
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Article
MiR-199a-5p-containing macrophage-derived extracellular vesicles inhibit SMARCA4 and alleviate atherosclerosis by reducing endothelial cell pyroptosis
Endothelial cell disturbance underpins a role in pathogenesis of atherosclerosis. Notably, accumulating studies indicate the substantial role of microRNAs (miRs) in atherosclerosis, and miR-199a-5p dysregulati...
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Article
Eugenol-Containing Siloxane Synthesized Via Heterogeneous Catalytic Hydrosilylation and its Application in Preparation of Superb Viscoelastic Low Modulus Gels
Eugenol is widely used as bio-based raw materials, based on functional groups such as hydroxyl, methoxy, and allyl contained in the molecule that has van der Waals forces or chemical reactivity. In this paper,...
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Article
Downregulation of CEMIP enhances radiosensitivity by promoting DNA damage and apoptosis in colorectal cancer
Colorectal cancer (CRC) is the third leading malignancy worldwide in both new cases and deaths. Neoadjuvant radiotherapy is the standard preoperative regimens for locally advanced patients. However, approximat...
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Article
Open AccessThe interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis
Nuclear protein 1 (NUPR1) is a transcriptional coregulator that has been implicated in the development of various cancer types. In addition, de novo fatty acid synthesis plays a pivotal role in hepatocellular ...
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Article
Open AccessTXN inhibitor impedes radioresistance of colorectal cancer cells with decreased ALDH1L2 expression via TXN/NF-κB signaling pathway
Colorectal cancer (CRC) is prevalent worldwide and is often challenged by treatment failure and recurrence due to resistance to radiotherapy. Here, we aimed to identify the elusive underlying molecular mechani...
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Article
Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions
The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe–host interactions in COPD through an in-depth ...
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Article
Immune microenvironment-related gene map** predicts immunochemotherapy response and prognosis in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma (NHL). The R-CHOP immunochemotherapy regimen is the first-line treatment option for DLBCL patients and has greatly imp...
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Article
Open AccessLINC01116 facilitates colorectal cancer cell proliferation and angiogenesis through targeting EZH2-regulated TPM1
Colorectal cancer (CRC) is a common malignant tumor globally. Meanwhile, LINC01116 has been proposed as risk factor for various tumors, including CRC. But the regulation of LINC01116 in CRC required more valid...
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Article
Carbon nanotube–mediated antibody-free suspension array for determination of typical endocrine-disrupting chemicals
A carbon nanotube (CNT)–mediated antibody-free suspension array (CASA) by integration of functionalized CNTs and aptamer (Apt) into xMAP® technology for simultaneous determination of typical endocrine-disrupti...
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Article
Open AccessEnhanced expression of TWIK-related arachidonic acid-activated K+ channel in the spinal cord of detrusor overactivity rats after partial bladder outlet obstruction
Detrusor overactivity (DO) secondary to partial bladder outlet obstruction (PBOO) is closely associated with alteration of ion channels. The objective of this study is to investigate the expression of the TWIK...
