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Article
Clinical analysis of twenty-one cases of acute ischemic stroke related to Trousseau syndrome
Trousseau syndrome (TS) is relatively rare and easily overlooked by clinicians, causing misdiagnosis and affecting subsequent treatment.
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Article
Open AccessThe MYBL2–CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages
An immunosuppressive tumor microenvironment in ovarian cancer facilitates tumor progression and resistance to immunotherapy. The function of MYB Proto-Oncogene Like 2 (MYBL2) in the tumor microenvironment rema...
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Article
Determination of the \(^{232}Th(n,\gamma )\) cross section from 10 to 200 keV at the Back-n facility at CSNS
The neutron capture cross section of \(^{232}Th\) ...
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Article
Open AccessIodine Deficiency of Breastfeeding Mothers and Infants from 2012 to 2019 in Zhengzhou, China
To investigate iodine status and characteristics of breastfeeding women and infants in Zhengzhou after the implementation of the new national standard of iodine in edible salt, so as to provide the basis for f...
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Article
Open AccessAmbient fine particulate matter and allergic symptoms in the middle-aged and elderly population: results from the PIFCOPD study
The associations between short- and long-term exposure to ambient fine particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM2.5) and allergic symptoms in middle-aged and elderly populations remain unclear,...
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Chapter
Multi-Omics Data Analysis for Inflammation Disease Research: Correlation Analysis, Causal Analysis and Network Analysis
In recent decades, an enormous amount of research on the human gut microbiota has established that it is strongly associated with human health and is involved in the occurrence and development of a variety of ...
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Article
Low-dose antiplatelet therapy survey after intracerebral hemorrhage in China: a retrospective hospital-based study
Restarting of antiplatelet therapy (AT) for patients with a history of intracerebral hemorrhage (ICH) is still a clinical dilemma in China. We aimed to investigate the association between low-dose AT and the l...
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Open AccessAssociation with CYP2C19 polymorphisms and Clopidogrel in treatment of elderly stroke patients
Clopidogrel is an antiplatelet drug used in the treatment of ischemic stroke. Safety and efficacy of clopidogrel has been confirmed in CAPRIE, PRoFESS trials. However, these studies focused on patients aged le...
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Article
Demographic and morphological characteristics associated with rupture status of anterior communicating artery aneurysms
The aim of this study is to characterize demographic and morphologic characteristics of aneurysms located in the anterior communicating artery (ACoA) and to investigate possible associations between these char...
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Article
Open AccessComparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population
Chronic obstructive pulmonary disease (COPD) is a major public health problem and cause of mortality worldwide. However, COPD in the early stage is usually not recognized and diagnosed. It is necessary to esta...
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Article
Endovascular treatment of ruptured intracranial aneurysms in elderly patients: clinical features and treatment outcome
Management of ruptured intracranial aneurysm in elderly patients is still a major challenge in the treatment of cerebrovascular disease. This study aimed to evaluate safety and efficacy profiles of ruptured in...
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Article
Open AccessExcessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
N6-methyladenosine (m6A) modification is an important mechanism in miRNA processing and maturation, but the role of its aberrant regulation in human diseases remained unclear. Here, we demonstrate that oncogenic ...
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Open AccessTranslational oncology toward benefiting cancer patients: the Sun Yat-sen University Cancer Center experience
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Article
Open AccessGenome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese
Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infe...
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Article
Correction: Corrigendum: Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women
Nature Communications 5: Article number: 4682 (2014); Published: 19 August 2014; Updated: 17 December 2014. The original version of the Supplementary Information attached to this Article contained an error in ...
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Article
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population
Dongxin Lin and colleagues report a genome-wide association study for laryngeal squamous cell carcinoma (LSCC) in Chinese populations. They identify three loci newly associated with LSCC.
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Article
Corrigendum: Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
Nat. Genet. 44, 1090–1097 (2012); published online 9 September 2012; corrected after print 27 August 2014 In contrast to the version of this article initially published, the authors find that there is now no e...
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Article
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations
Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...
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Article
Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women
Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variant...
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Article
New loci associated with chronic hepatitis B virus infection in Han Chinese
Hongbing Shen and colleagues report a genome-wide association study for chronic hepatitis B virus (HBV) infection in Han Chinese populations. They identify two loci newly associated with HBV infection near HLA-C ...
