-
Article
Open AccessExtracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma
Anlotinib is a targeted therapy indicated for some malignancies, including advanced non-small cell lung cancer (NSCLC). However, noninvasive biomarkers for identifying patients who will benefit from this disea...
-
Article
Open AccessComplete transection of the bilateral main bronchus in a 5-year-old patient: a case report
Tracheobronchial injuries caused by blunt chest trauma are rare in children, and such injuries usually involve multiple organs. Most cases involve respiratory failure on the way to the hospital, and the mortal...
-
Article
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway
The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of SMAD6 are recurrently found in indi...
-
Article
Open AccessSafety and efficacy of multi-target TKI combined with nivolumab in check-point inhibitor-refractory patients with advanced NSCLC: a prospective, single-arm, two-stage study
Resistance to immune checkpoint inhibitors (ICIs) represents a major unmet medical need in non-small cell lung cancer (NSCLC) patients. Vascular endothelial growth factor (VEGF) inhibition may reverse a suppre...
-
Article
Open AccessRelationship between jejunum ATPase activity and antioxidant function on the growth performance, feed conversion efficiency, and jejunum microbiota in Hu sheep (Ovis aries)
ATPase activity and the antioxidant function of intestinal tissue can reflect intestinal cell metabolic activity and oxidative damage, which might be related to intestinal function. However, the specific influ...
-
Article
Evolution of Microstructure and Mechanical Properties of DP590 Structural Steel of Vehicle in Heat-Treatment Post-Fire Simulation
To investigate the post-fire change of the microstructure and properties of a vehicle body made of DP590 structural steel, this study simulated the post-fire process of a vehicle by considering heating process...
-
Article
Open AccessInsulin Degludec in People with Type 2 Diabetes in China: A Non-interventional, Retrospective Chart Review Study (CN-TREAT)
Insulin degludec (degludec), an ultra-long-acting basal insulin analogue, provides equivalent glycemic control to other basal insulin analogues, with lower risk of hypoglycemia and flexible dosing. Chinese TRE...
-
Article
Dietary betaine and/or TMAO affect hepatic lipid accumulation and glycometabolism of Megalobrama amblycephala exposed to a high-carbohydrate diet
A 12-week experiment was conducted to explore the effects of betaine and/or TMAO on growth, hepatic health, gut microbiota, and serum metabolites in Megalobrama amblycephala fed with high-carbohydrate diets. The ...
-
Chapter and Conference Paper
Enhancing Lidar and Radar Fusion for Vehicle Detection in Adverse Weather via Cross-Modality Semantic Consistency
The fusion of multiple sensors such as Lidar and Radar provides richer information and thus improves the perception ability for autonomous driving even in adverse weather. However, Lidar paints 3D geometric po...
-
Chapter and Conference Paper
An Unbalance Identification Method of a Whole Aero-Engine Based on the Casing Vibrations
Squeeze film dampers (SFDs) have been frequently employed in aero-engines due to their excellent vibration reduction performance. However, their nonlinear characteristics make it difficult for traditional bala...
-
Chapter and Conference Paper
Broaden Your Positives: A General Rectification Approach for Novel Class Discovery
Novel category discovery (NCD), which is a challenging and emerging task, aims to cluster unlabelled instances with knowledge information transferred from labelled ones. A majority of recent state-of-the-art m...
-
Article
A refined functional group approach reveals novel insights into effects of urbanization on river macroinvertebrate communities
Urbanization-induced environmental changes are key causes of community disassembly in freshwater systems. Given that species’ traits are closely linked to environmental tolerances, trait-based approaches allow...
-
Article
Open AccessAttenuates reactive oxygen species: induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in models of trigeminal neuralgia
In this study, we examined the impact of demyelinating and neuroinflammation on trigeminal neuralgia (TN) by utilizing models of chronic constriction injury to the infraorbital nerve (CCI). The CCI rats were t...
-
Article
Low-threshold mid-infrared ZGP optical parametric oscillator pumped by wavelength-selectable Tm:YLF laser at 1.93 μm
We demonstrated a mid-infrared (MIR) ZGP optical parametric oscillator (OPO) which was pumped by an acousto-optically Q-switched Tm:YLF laser operated at 1.93 μm for the first time. The pump wavelength was rea...
-
Article
RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice
Activation of T cells and pro-inflammatory cytokines are essential for human autoimmune hepatitis. RAGE is one of the receptors for the inflammatory alarm molecule high mobility group box 1 (HMGB1), and it is ...
-
Article
Population genetics and phylogeography of Paramisgurnus dabryanus (Cypriniformes: Cobitidae) in six river basins of China
The present study aimed to investigate the population genetics of Paramisgurnus dabryanus across six river basins in China. Two mitochondrial genes (Cytochrome b and control region) and 12 microsatellite markers ...
-
Article
Ti4+ functionalized β-cyclodextrin covalent organic framework as a new immobilized metal ion affinity chromatography platform for selective capture of phosphorylated peptides and exosomes
A Ti4+ functionalized β-cyclodextrin covalent organic framework nanoparticle (named as β-CD-COF@Ti4+) was synthesized using a one-pot method successfully realizing the enrichment of phosphorylated peptides and ex...
-
Article
Distribution and potential health risks of perfluoroalkyl substances (PFASs) in water, sediment, and fish in Dongjiang River Basin, Southern China
Per- and polyfluoroalkyl substances (PFASs) have attracted worldwide attention due to their high stability, refractory degradation, and bioaccumulation. The Dongjiang River is one of the most important water s...
-
Article
Open AccessHeritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs
Heritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen microbiota interactions and their association with phenotype i...
-
Article
Open AccessContribution of boundary non-stoichiometry to the lower-temperature plasticity in high-pressure sintered boron carbide
The improvement of non-oxide ceramic plasticity while maintaining the high-temperature strength is a great challenge through the classical strategy, which generally includes decreasing grain size to several na...
