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Article
A new gold(I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis. It is frequently overexpressed in various cancer cells, including prostate cancer, making it a promising target for the development of ...
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Article
Open AccessMannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...
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Article
Combination of a reaction cell and an ultra-high vacuum system for the in situ preparation and characterization of a model catalyst
An in-depth understanding of the structure–activity relationship between the surface structure, chemical composition, adsorption and desorption of molecules, and their reaction activity and selectivity is nece...
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Article
Open AccessRab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
Stomach adenocarcinoma (STAD) is one of the leading causes of cancer-related death globally. Metastasis and drug resistance are two major causes of failures in current chemotherapy. Here, we found that the exp...
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Article
Open AccessClinical and genomic features in patients with second primary glioblastoma following first primary renal cell carcinoma
To explore the potential pathogenesis and clinical features of second primary glioblastoma (spGBM) following first primary renal cell carcinoma (fpRCC).
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Article
Open AccessHK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) i...
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Article
Open AccessMachine learning-based Radiomics analysis for differentiation degree and lymphatic node metastasis of extrahepatic cholangiocarcinoma
Radiomics may provide more objective and accurate predictions for extrahepatic cholangiocarcinoma (ECC). In this study, we developed radiomics models based on magnetic resonance imaging (MRI) and machine learn...
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Article
Open AccessThe metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8
Pyroptosis is a form of regulated cell death mediated by gasdermin family members, among which the function of GSDMC has not been clearly described. Herein, we demonstrate that the metabolite α-ketoglutarate (...
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Article
Open AccessArgonaute 2 is a key regulator of maternal mRNA degradation in mouse early embryos
In mammalian early embryos, the transition from maternal to embryonic control of gene expression requires timely degradation of a subset of maternal mRNAs (MRD). Recently, zygotic genome activation (ZGA)-depen...
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Article
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange
Mitochondrial homeostasis depends on mitophagy, the programmed degradation of mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a multidimensional CRISPR–Cas9 genetic scr...
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Article
Serratia microhaemolytica sp. nov., isolated from an artificial lake in Southern China
A Gram-stain negative, facultatively anaerobic, rod-shaped, non-motile and non-spore forming bacterium, designated ZS-11T, was isolated from an artificial freshwater lake in Guangzhou city, Guangdong province, Ch...
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Article
Side-Channel Analysis for the Authentication Protocols of CDMA Cellular Networks
Time-division multiple access (TDMA) and code-division multiple access (CDMA) are two technologies used in digital cellular networks. The authentication protocols of TDMA networks have been proven to be vulner...
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Article
HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells
Long non-coding RNAs (LncRNAs) exert their functions mainly by binding to their corresponding proteins. Runt-related transcription factor 3 (Runx3) is an important transcription factor that functions as a tumo...
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Article
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation
A negative regulator of the Wnt pathway secreted by tumor cells promotes immune evasion by suppressing lymphocyte cytotoxicity.
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Article
Preparation of POE/PS blends with fine particle sizes by diffusion and subsequent polymerization of styrene in POE pellets
Ethylene-α-octene copolymer (POE)/polystyrene (PS) blend pellets with fine particle sizes were prepared by diffusion and subsequent polymerization of styrene in POE pellets through a one-pot procedure. The effect...
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Article
Open AccessNur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates g...
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Article
Open AccessMalaria from hyperendemicity to elimination in Hekou County on China–Vietnam border: an ecological study
Malaria control and elimination are challenged by diversity and complexity of the determinants on the international border in the Great Mekong Sub-region. Hekou, a Chinese county on the China–Vietnam border, w...
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Article
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
The orphan nuclear receptor Nur77 blocks inflammation through inhibition of p65 DNA binding and is suppressed by p38α-mediated phosphorylation. A small-molecule compound, PDNPA, disrupts p38α-Nur77 interaction...
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Article
Effect of the shell crosslinking level and Core/Shell ratio on the morphology of latex particles in the preparation of hollow latexes
Three-layer core/shell latex particles with various shell crosslinking level and shell thickness were prepared by multistep emulsion polymerization, and the hollow latex particles with different morphologies w...
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Article
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...
