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  1. No Access

    Article

    Genetic architecture of subcortical brain structures in 38,851 individuals

    Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate n...

    Claudia L. Satizabal, Hieab H. H. Adams, Derrek P. Hibar… in Nature Genetics (2019)

  2. No Access

    Article

    Genomic segmental polymorphisms in inbred mouse strains

    By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification o...

    Jiangzhen Li, Tao Jiang, Jian-Hua Mao, Allan Balmain, Leif Peterson… in Nature Genetics (2004)

  3. No Access

    Article

    Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays

    Chromosomal imbalances such as deletions and amplifications are common rearrangements in most tumors1. Specific rearrangements are consistently associated with specific tumor types or stages, implicating the role...

    Wei-Wen Cai, Jian-Hua Mao, Chi-Wen Chow, Shamsha Damani… in Nature Biotechnology (2002)

  4. No Access

    Article

    An SSLP marker–anchored BAC framework map of the mouse genome

    We have constructed a BAC framework map of the mouse genome consisting of 2,808 PCR-confirmed BAC clusters, using a previously described method1. Fingerprints of BACs from selected clusters confirm the accuracy o...

    Wei-Wen Cai, Chi-Wan Chow, Shamsha Damani, Simon G. Gregory, Marco Marra… in Nature Genetics (2001)

  5. No Access

    Article

    Engineering a mouse balancer chromosome

    Balancer chromosomes are genetic reagents that are used in Drosophila melanogaster for stock maintenance and mutagenesis screens1. Despite their utility, balancer chromosomes are rarely used in mice because they ...

    Binhai Zheng, Marijke Sage, Wei-Wen Cai, Debrah M. Thompson… in Nature Genetics (1999)