11 Result(s)

Article

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

Lung cancer is the leading cause of cancer death, partially owing to its extensive heterogeneity. The analysis of intertumor heterogeneity has been limited by an inability to concurrently obtain tissue from sy...

Runzhe Chen, Jun Li, Junya Fujimoto… in Journal of Experimental & Clinical Cancer … (2022)

Article

The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics

Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are largely unknown. We conduct whole-exome sequencing an...

Ming Tang, Hussein A. Abbas, Marcelo V. Negrao… in Nature Communications (2021)

Article

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Small-cell lung cancer (SCLC) is speculated to harbor complex genomic intratumor heterogeneity (ITH) associated with high recurrence rate and suboptimal response to immunotherapy. Here, using multi-region whol...

Ming Chen, Runzhe Chen, Ying **, Jun Li, **n Hu, Jiexin Zhang… in Nature Communications (2021)

Article

Author Correction: Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

**n Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa… in Nature Communications (2021)

Article

Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by ...

Hitoshi Dejima, **n Hu, Runzhe Chen, Jiexin Zhang, Junya Fujimoto… in Nature Communications (2021)

Article

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

The evolution of DNA methylome and methylation intra-tumor heterogeneity (ITH) during early carcinogenesis of lung adenocarcinoma has not been systematically studied. We perform reduced representation bisulfit...

**n Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben… in Nature Communications (2021)

Article

Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

Metastasis is the primary cause of cancer mortality accounting for 90% of cancer deaths. Our understanding of the molecular mechanisms driving metastasis is rudimentary.

Won-Chul Lee, Alexandre Reuben, **n Hu, Nicholas McGranahan, Runzhe Chen… in Genome Biology (2020)

Article

Comprehensive T cell repertoire characterization of non-small cell lung cancer

Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NS...

Alexandre Reuben, Jiexin Zhang, Shin-Heng Chiou… in Nature Communications (2020)

Article

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

There has been a dramatic increase in the detection of lung nodules, many of which are preneoplasia atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA)...

**n Hu, Junya Fujimoto, Lisha Ying, Junya Fukuoka, Kazuto Ashizawa… in Nature Communications (2019)

Article

Genomic heterogeneity of multiple synchronous lung cancer

Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15...

Yu Liu, Jianjun Zhang, Lin Li, Guangliang Yin, Jianhua Zhang… in Nature Communications (2016)