-
Article
Open AccessPublisher Correction: Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor‑like population
-
Article
Open AccessTranscriptome analysis identifies an ASD-Like phenotype in oligodendrocytes and microglia from C58/J amygdala that is dependent on sex and sociability
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with higher incidence in males and is characterized by atypical verbal/nonverbal communication, restricted interests that can be accomp...
-
Article
Open AccessAccelerated epigenetic age is associated with whole-brain functional connectivity and impaired cognitive performance in older adults
While chronological age is a strong predictor for health-related risk factors, it is an incomplete metric that fails to fully characterize the unique aging process of individuals with different genetic makeup,...
-
Article
Open AccessSpatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche
Glioblastoma (GBM) remains an untreatable malignant tumor with poor patient outcomes, characterized by palisading necrosis and microvascular proliferation. While single-cell technology made it possible to char...
-
Article
Open AccessGanglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Gangliogliomas are brain tumors composed of neuron-like and macroglia-like components that occur in children and young adults. Gangliogliomas are often characterized by a rare population of immature astrocyte-...
-
Article
Open AccessThe effect of oxytocin nasal spray on social interaction in young children with autism: a randomized clinical trial
Early supports to enhance social development in children with autism are widely promoted. While oxytocin has a crucial role in mammalian social development, its potential role as a medication to enhance social...
-
Article
Open AccessGenetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression
The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric ...
-
Article
Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessCirculating MicroRNA Profiling in Non-ST Elevated Coronary Artery Syndrome Highlights Genomic Associations with Serial Platelet Reactivity Measurements
Changes in platelet physiology are associated with simultaneous changes in microRNA concentrations, suggesting a role for microRNA in platelet regulation. Here we investigated potential associations between mi...
-
Article
Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism
The immune system plays a multifunctional role throughout the regenerative process, regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present study, we identify the myokine/cyt...
-
Chapter
Genetics of the Chiari I and II Malformations
Chiari malformations are considered to have a multifactorial etiology, likely influenced by environmental and genetic factors. This chapter will detail the evidence that supports a genetic contribution to the ...
-
Article
Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair
Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or Flt3—to identify the precursors of oste...
-
Article
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin
The size of immune-cell populations needs to be tightly regulated. Shinohara and colleagues demonstrate that intracellular and secreted osteopontin control the contraction and expansion of myeloid and lymphoid...
-
Article
Open AccessGenome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FEC...
-
Article
An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage
Experimental autoimmune encephalomyelitis can be induced by strong activation of innate immunity. This subtype of EAE is resistant to interferon (IFN)-β treatment and is NLRP3 inflammasome independent. Its dev...
-
Article
Human centromere repositioning within euchromatin after partial chromosome deletion
Centromeres are defined by a specialized chromatin organization that includes nucleosomes that contain the centromeric histone variant centromere protein A (CENP-A) instead of canonical histone H3. Studies in ...
-
Article
Open AccessJoint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation
Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue an...
-
Article
Open AccessIdentification of Chiari Type I Malformation subtypes using whole genome expression profiles and cranial base morphometrics
Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the foramen magnum at the base of the skull, resulting in significant neurologic morbidity. As CMI patients dis...
-
Article
Gene–smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort
We performed a gene–smoking interaction analysis using families from an early-onset coronary artery disease cohort (GENECARD). This analysis was focused on validating and expanding results from previous studie...
-
Article
Open AccessInteractions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China
Existing literature indicates that ADRB2 gene is associated with health and longevity, but none of previous studies investigated associations of carrying the ADRB2 minor alleles and interactions between ADRB2 ...
