45 Result(s)

Article

OliTag-seq enhances in cellulo detection of CRISPR-Cas9 off-targets

The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleot...

Zhi-Xue Yang, Dong-Hao Deng, Zhu-Ying Gao, Zhi-Kang Zhang… in Communications Biology (2024)

Article

Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation

Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2 inflammation. However, the underlying mechanism remains uncertai...

**umin Chen, Changhui Chen, Zhaoxu Tu, Zeling Guo, Tong Lu, Jian Li… in Cell Death Discovery (2024)

Article

Spatio-temporal patterns in the biomass, species composition and nitrogen content of drift macroalgae in an urbanised coastal embayment

Understanding spatio-temporal variability in the production of drift macroalgae is useful for monitoring and assessing the influence of local anthropogenic nutrient sources on coastal ecosystems. In this study...

Juan Manuel Valero-Rodriguez, Tim Dempster, Wei Wen Wong… in Journal of Applied Phycology (2024)

Article

Metabolomic and genome-wide association studies drive genetic dissection and gene mining in tea plant

As a vital reproductive organ, flowers significantly influence the yield, sensory quality, and breeding efficacy of Camellia sinensis. Many biological characteristics of tea plants are influenced by metabolites; ...

**aohui Jiang, **g**g Zhao, Dawei Gao, **aoliang Zhang… in Horticulture Advances (2024)

Article

Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing

CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively cur...

Juan-Juan Zhao, **n-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin… in BMC Genomics (2024)

Article

CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA

Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...

Chunyu Zhang, Li Yuan, Qiaojian Zou, Caixia Shao… in Cellular & Molecular Biology Letters (2024)

Article

The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology

The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL...

Huantian Cui, Ning Wang, Hanzhou Li, Yuhong Bian… in Cell Communication and Signaling (2024)

Article

The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewe...

Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai… in Cell Communication and Signaling (2023)

Article

Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis

Natural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells offer an 'off-the-sh...

Wei Wen, **ang Chen, **n-Yi Shen, Hua-Yu Li, Feng Zhang… in Stem Cell Research & Therapy (2023)

Article

Three-dimensional branch segmentation and phenotype extraction of maize tassel based on deep learning

The morphological structure phenotype of maize tassel plays an important role in plant growth, reproduction, and yield formation. It is an important step in the distinctness, uniformity, and stability (DUS) te...

Wenqi Zhang, Sheng Wu, Weiliang Wen, **anju Lu, Chuanyu Wang, Wenbo Gou… in Plant Methods (2023)

Article

Characterization of novel loci controlling seed oil content in Brassica napus by marker metabolite-based multi-omics analysis

Seed oil content is an important agronomic trait of Brassica napus (B. napus), and metabolites are considered as the bridge between genotype and phenotype for physical traits.

Long Li, Zhitao Tian, Jie Chen, Zengdong Tan, Yuting Zhang, Hu Zhao… in Genome Biology (2023)

Article

Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors

Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies have many challenges due to its inconsistent potency and limited quantity. Here, we report a strategy to generate induced ...

Wanqiu Chen, Chenguang Wang, Zhi-Xue Yang, Feng Zhang, Wei Wen… in Communications Biology (2023)

Article

Integrating multiomics data accelerates elucidation of plant primary and secondary metabolic pathways

Plants are the most important sources of food for humans, as well as supplying many ingredients that are of great importance for human health. Develo** an understanding of the functional components of plant ...

Feng Zhu, Weiwei Wen, Yunjiang Cheng, Saleh Alseekh, Alisdair R. Fernie in aBIOTECH (2023)

Article

Proximal tubule-derived exosomes contribute to mesangial cell injury in diabetic nephropathy via miR-92a-1-5p transfer

Diabetic nephropathy (DN) is an increasing threat to human health and regarded to be the leading cause of end-stage renal disease worldwide. Exosomes delivery may play a key role in cross-talk among kidney cel...

Yi-Chun Tsai, Mei-Chuan Kuo, Wei-Wen Hung, **-Hsun Wu… in Cell Communication and Signaling (2023)

Article

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling

Chromodomain helicase DNA binding protein (CHD) family plays critical roles in regulating gene transcription. The family is linked to cancer disease, but the family member’s role in tumorigenesis remains largely ...

Boyu Zhang, Qingxin Liu, Weijie Wen, Han Gao, Wenxia Wei, Aiwen Tang… in Cell Discovery (2022)

Article

The dual antimicrobial and immunomodulatory roles of host defense peptides and their applications in animal production

Host defense peptides (HDPs) are small molecules with broad-spectrum antimicrobial activities against infectious bacteria, viruses, and fungi. Increasing evidence suggests that HDPs can also indirectly protect...

Di Wu, Linglong Fu, Weizhang Wen, Na Dong in Journal of Animal Science and Biotechnology (2022)

Article

Transcription factor CsESE3 positively modulates both jasmonic acid and wax biosynthesis in citrus

PLIP lipases can initiate jasmonic acid (JA) biosynthesis. However, little is known about the transcriptional regulation of this process. In this study, an ERF transcription factor (CsESE3) was found to be co-exp...

Haoliang Wan, Haiji Qiu, Zhuoran Li, **aoliang Zhang, **gyu Zhang… in aBIOTECH (2022)

Article

Effects and potential of optimized fertilization practices for rice production in China

Optimized fertilization practices are a promising management strategy for sustainable rice production. Green manuring, straw incorporation, postponing nitrogen (N) application, formula fertilization, combined ...

Yanhua Zhuang, Shuhe Ruan, Liang Zhang… in Agronomy for Sustainable Development (2022)

Article

Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA inte...

Wei Wen Teo, **nang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou… in Communications Biology (2022)

Article

Correction to: Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt

Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed… in BMC Genomics (2022)