130 Result(s)
within
Wei** Jia
Life Sciences
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Article
Open AccessMechanism and bioinformatics analysis of the effect of berberine-enhanced fluconazole against drug-resistant Candida albicans
Biofilms produced by Candida albicans present a challenge in treatment with antifungal drug. Enhancing the sensitivity to fluconazole (FLC) is a reasonable method for treating FLC-resistant species. Moreover, sev...
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Open AccessComparative profiling of serum, urine, and feces bile acids in humans, rats, and mice
Bile acids (BAs) play important pathophysiological roles in both humans and mammalian animals. Laboratory rats and mice are widely used animal models for assessing pharmacological effects and their underlying ...
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A new gold(I) phosphine complex induces apoptosis in prostate cancer cells by increasing reactive oxygen species
Thioredoxin reductase (TrxR) is a pivotal regulator of redox homeostasis. It is frequently overexpressed in various cancer cells, including prostate cancer, making it a promising target for the development of ...
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Open AccessA protoplast-based transient gene expression assay for the identification of heat and oxidative stress-regulatory genes in perennial ryegrass
With the accumulating omics data, an efficient and time-saving transient assay to express target genes is desired. Mesophyll protoplasts, maintaining most stress-physiological responses and cellular activities...
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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabol...
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Open AccessUnveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature driving ESCC progression remains elusive. Here, we show that methionine ...
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SbYS1 and SbWRKY72 regulate Cd tolerance and accumulation in sweet sorghum
SbYS1 and its upstream transcription factor SbWRKY72 were involved in Cd tolerance and accumulation and are valuable for develo** sweet sorghum germplasm with high-Cd tolerance or accumulation ability throug...
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Open AccessEpidemiology and molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolated from neonatal intensive care units in General Hospital of Ningxia Medical University, China, 2017–2021
This study aimed to retrospectively investigate the epidemiology and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from neonatal intensive care units (NICU) between 2017 ...
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Effects of Natural Diffused Light Storage on Highland Seed Potatoes and Subsequent Field Performance in Lowland
Potato (Solanum tuberosum L.) is an essential staple crop in China. Appropriate storage methods and technology are critical to ensure the quality of seed potatoes, which is closely related to the field performanc...
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Open AccessResistant starch intake facilitates weight loss in humans by resha** the gut microbiota
Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 3...
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Compatible taper and volume systems for Larix olgensis and Larix kaempferi in northeast China
Accurate estimation of tree stem form and merchantable volume is an important prerequisite for forest management and economic evaluation. A system of compatible taper-volume equations was constructed for estim...
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Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1
Cytokinins are essential for plant growth and development, and their tissue distributions are regulated by transmembrane transport. Recent studies have revealed that members of the ‘Aza-Guanine Resistant’ (AZG...
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Open AccessGenomic and phenotypic analysis of a novel clinical isolate of Corynebacterium pyruviciproducens
Corynebacterium pyruviciproducens is a recently described species of Corynebacterium. There are few reports on the microbiological characteristics of the new species, and there is a lack of reports on the genomic...
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Open AccessMannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyroptosis is negatively regulated remains unclear. Here, we demonstrate that mannose, a hexos...
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Article
Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery
Urinary extracellular vesicles (EVs) have gained increasing interest in recent years as a potential source of noninvasive biomarkers of diseases related to urinary organs, but knowledge of the mechanism is sti...
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Altitude rather than season and slope aspect has the greatest effect on the bacterial communities in subtropical forests in Yunnan, China
Altitude, season, and slope aspect have significant impacts on bacterial variation in forest soils. However, it is currently unclear which factor has the greatest influence.
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Open AccessIodine Deficiency of Breastfeeding Mothers and Infants from 2012 to 2019 in Zhengzhou, China
To investigate iodine status and characteristics of breastfeeding women and infants in Zhengzhou after the implementation of the new national standard of iodine in edible salt, so as to provide the basis for f...
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Open AccessSingle-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver
A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been c...
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Open AccessAged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are pro...
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Open AccessSLC43A2 and NFκB signaling pathway regulate methionine/cystine restriction-induced ferroptosis in esophageal squamous cell carcinoma via a feedback loop
Studies have indicated dietary restriction of methionine/cystine provided a therapeutic benefit in diseases such as cancer. However, the molecular and cellular mechanisms that underlie the interaction between ...
