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Article
Open AccessFibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction
Acute myocardial infarction (AMI) is characterized by inflammation, oxidative stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein (HDL) takes a crucial part in mitig...
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Article
Comprehensive analysis of phenylpropanoids and butylidenephthalides in Angelica sinensis (Oliv.) Diels from different regions and processing methods by high-performance liquid chromatography combined with chemometrics
Angelicae sinensis radix is commonly used in Chinese medicine and is also widely used as a spice and condiment in many countries. Due to the different geographical sources and processing methods, the contents ...
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Chapter and Conference Paper
Application and Optimization of Shape Adjustment Design Based on “FAST” Active Reflector Model
For the establishment of an ideal parabolic reflector adjustment model and the optimization of the reception effect of celestial electromagnetic waves reflected by the reflector, it is a major problem in the a...
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Article
Fisher pruning for develo** real-time UAV trackers
Unmanned aerial vehicle (UAV)-based tracking has shown large potential in various domains such as transportation, logistics, public safety, and more. However, deploying deep learning (DL)-based tracking algori...
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Article
Open AccessSIRT2 regulates extracellular vesicle-mediated liver–bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 express...
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Article
Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis
Lipid metabolism participates in various biological processes such as proliferation, apoptosis, migration, invasion, and maintenance of membrane homeostasis of prostate tumor cells. Bufadienolides, the active ...
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Article
Quantitative imaging of natural products in fine brain regions using desorption electrospray ionization mass spectrometry imaging (DESI-MSI): Uncaria alkaloids as a case study
Uncaria species (Rubiaceae) are used as traditional Chinese medicines (TCMs) to treat central nervous system (CNS) diseases, and monoterpene indole alkaloids are the main bioactive constituents. Localization and ...
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Article
Open AccessExploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing
Previous studies have demonstrated the highly specific expression of circular RNAs (circRNAs) in different tissues and organisms, but the cellular architecture of circRNA has never been fully characterized. He...
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Article
Quantitative and fingerprint analysis of proanthocyanidins and phenylpropanoids in Cinnamomum verum bark, Cinnamomum cassia bark, and Cassia twig by UPLC combined with chemometrics
Cinnamomum verum and Cinnamomum cassia are widely used as spice and herbal medicine around the world. However, it is challenging to differentiate and make a quality evaluation for both Cinnamomum types due to the...
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Article
“Force iteration molecular designing” strategy for the systematic characterization and discovery of new protostane triterpenoids from Alisma Rhizoma by UHPLC/LTQ-Orbitrap-MS
Comprehensive analysis and identification of chemical components are of great significance for evaluating the efficacy and safety of herbal medicines, as well as for drug exploitation and development. Here we ...
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Article
Open AccessCancer patient management strategy in a Cancer Center of Zhejiang, China during the COVID-19 pandemic
Due to the increased risk of viral infection and the severe shortage of medical resources during the pandemic of COVID-19, most hospitals in the epidemic areas significantly reduced non-emergency admissions an...
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Article
Open AccessDevelopment and validation of oral chemotherapy self-management scale
With the increase of oral chemotherapy drugs, patients receiving cancer treatment prefer oral chemotherapy versus intravenous, given equal efficacy and toxicity. However, they need to take an active part in th...
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Article
Open AccessCircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes
Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate circRNA prioritization. To address this, we integ...
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Article
An unexpected reaction of cinobufagin analogues in the presence of PPh3/I2
An unexpected reaction of cinobufagin analogues in the presence of PPh3/I2 in EtOAc at room temperature to obtain diene compounds has been described. The whole process is carried out under mild conditions and the...
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Article
Palladium-catalyzed carbonylative Sonogashira cross-coupling for the synthesis of alkynones with formic acid as the CO source
A practical and efficient palladium-catalyzed carbonylative Sonogashira cross-coupling reaction for the synthesis of alkynones from aryl iodides, alkynes, and formic acid as the CO source has been described. U...
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Article
Enhanced adsorption of uranium by modified red muds: adsorption behavior study
Uranium is a hazardous and radioactive element. Effective removal of uranium from wastewater stream requires advanced functional materials and reliable technologies. Red mud is a type of low-cost adsorbent whi...
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Article
An intelligentized strategy for endogenous small molecules characterization and quality evaluation of earthworm from two geographic origins by ultra-high performance HILIC/QTOF MSE and Progenesis QI
Animal-derived medicines have been a vital component for traditional Chinese medicine. However, their quality control remains challenging due to the large polarity of the contained endogenous small molecules (...
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Article
Neutral Loss Ion Map** Experiment Combined with Precursor Mass List and Dynamic Exclusion for Screening Unstable Malonyl Glucoside Conjugates
Malonates are one type of the acylation conjugates and found abundantly in ginseng and soybean. Malonyl conjugates of ginsenosides and isoflavone glycosides were often considered as the characteristic componen...
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Article
An integrated strategy for the systematic characterization and discovery of new indole alkaloids from Uncaria rhynchophylla by UHPLC/DAD/LTQ-Orbitrap-MS
The exploration of new chemical entities from herbal medicines may provide candidates for the in silico screening of drug leads. However, this significant work is hindered by the presence of multiple classes o...
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Article
Open AccessBaicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
Baicalein, a natural flavonoid obtained from the Scutellaria baicalensis root, has been reported to inhibit growth of human lung cancer. However, the detailed mechanism underlying this has not been well elucid...
