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Article
miR-29c Suppresses the Malignant Phenotype of Hepatocellular Carcinoma Cells In Vitro by Mediating TPX2 Associated with Immune Infiltration
miR-29-3p, an important tumor suppressor, with inhibitory effects in multiple cancers that have been studied. Its exact molecular function is in HCC, however, still not been explored clearly. The purpose of ou...
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Article
Development and validation of a model for predicting the adult height of girls with idiopathic central precocious puberty
The aim was to develop a model to predict the adult height (AH) of idiopathic central precocious puberty (ICPP) girls who underwent gonadotropin-releasing hormone analog (GnRHa) treatment. Data analysis inclu...
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Article
Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis
Lipid metabolism participates in various biological processes such as proliferation, apoptosis, migration, invasion, and maintenance of membrane homeostasis of prostate tumor cells. Bufadienolides, the active ...
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Article
Open AccessNotch3 signaling promotes colorectal tumor growth by enhancing immunosuppressive cells infiltration in the microenvironment
Macrophage infiltration in the tumor microenvironment participates in the regulation of tumor progression. Previous studies have found that Notch signaling pathway is involved in regulating the progression of ...
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Article
Research on the Erosion Performance of a New Normally Open Arrow-Type Check Valve Spool
In this paper, the erosion performance of a new normally open arrow-type check valve spool was studied by the CFD method. The liquid phase is regarded as a continuous phase, and the particles are solved by a d...
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Article
Quantitative imaging of natural products in fine brain regions using desorption electrospray ionization mass spectrometry imaging (DESI-MSI): Uncaria alkaloids as a case study
Uncaria species (Rubiaceae) are used as traditional Chinese medicines (TCMs) to treat central nervous system (CNS) diseases, and monoterpene indole alkaloids are the main bioactive constituents. Localization and ...
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Article
Open AccessCorrection to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
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Article
Open AccessDeubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
Von Hippel-Lindau (VHL) is an important tumor suppressor, and its inactivation is a hallmark of inherited VHL disease and most sporadic clear cell renal cell carcinoma (ccRCC). VHL protein (pVHL) with missense...
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Article
“Force iteration molecular designing” strategy for the systematic characterization and discovery of new protostane triterpenoids from Alisma Rhizoma by UHPLC/LTQ-Orbitrap-MS
Comprehensive analysis and identification of chemical components are of great significance for evaluating the efficacy and safety of herbal medicines, as well as for drug exploitation and development. Here we ...
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Article
Assessment of the human health risks of heavy metals in nine typical areas
Human health risks of five different heavy metals were assessed in nine typical areas in Asia, Europe, and Africa. The geoaccumulation index (Igeo) of arsenic (As) in Hyderabad (HB), cadmium (Cd) in Veles (VL), a...
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Article
Effects of combined drip irrigation and sub-surface pipe drainage on water and salt transport of saline-alkali soil in **njiang, China
Develo** effective irrigation and drainage strategies to improve the quality of saline-alkali soil is vital for enhancing agricultural production and increasing economic returns. In this study, we explored h...
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Article
Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity
Checkpoint blockade enhances effector T cell function and has elicited long-term remission in a subset of patients with a broad spectrum of cancers. TIGIT is a checkpoint receptor thought to be involved in med...
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Article
Accumulation of heavy metals in soil-crop systems: a review for wheat and corn
The health risks arising from heavy metal pollution (HMP) in agricultural soils have attracted global attention, and research on the accumulation of heavy metals in soil-plant systems is the basis for human he...
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Article
Sensitization of 21% Cr Ferritic Stainless Steel Weld Joints Fabricated With/Without Austenitic Steel Foil as Interlayer
The effects of sensitization heat treatment on the microstructure and electrochemical behavior of 21% Cr ferritic stainless steel weld joints with or without 309L austenite stainless steel as an interlayer wer...
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Article
The geostatistic-based spatial distribution variations of soil salts under long-term wastewater irrigation
The purpose of this study was to determine and evaluate the spatial changes in soil salinity by using geostatistical methods. The study focused on the suburb area of Bei**g, where urban development led to wat...
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Article
Groundwater Vulnerability Assessment and Feasibility Map** Under Reclaimed Water Irrigation by a Modified DRASTIC Model
Increasing water shortages promote reclaimed water irrigation (RWI), which potentially causes additional contaminants in groundwater. The DRASTIC model has become an important tool to assess specific groundwat...
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Article
The Compensation Mechanism and Water Quality Impacts of Agriculture-Urban Water Transfers: A Case Study in China’s Chaobai Watershed
Water transfer from agriculture to urban uses will likely become increasingly common worldwide. The objectives of this study were to evaluate the effects of converting paddy rice to dry land crops (PPRDC) on l...
