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  1. Article

    Open Access

    KCC2 downregulation facilitates epileptic seizures

    GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl−] concentration, which in adult depends on neuron specific K+-Cl− cotransporter-2 (KCC2). Previous studies have shown t...

    Lulan Chen, Li Wan, Zheng Wu, Wanting Ren, Yian Huang, Binbin Qian… in Scientific Reports (2017)

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    Article

    Activation of extrasynaptic GABAA receptors inhibits cyclothiazide-induced epileptiform activity in hippocampal CA1 neurons

    Extrasynaptic GABAA receptors (GABAARs)-mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy. In this study, we used cyclothiazide (CTZ)-induced in vitro brain slice seizure model to e...

    Li Wan, Xu Liu, Zheng Wu, Wanting Ren, Shuzhen Kong… in Neuroscience Bulletin (2014)