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Article
The Circular RNA circFOXK2 Enhances the Tumorigenesis of Non-Small Cell Lung Cancer Through the miR-149-3p/IL-6 Axis
Circular RNAs (circRNAs) are the non-coding types of RNAs and are thoughts to be linked with human cancer progression. circFOXK2 is believed to be associated with cancers, however, the molecular mechanisms of ...
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Article
Open AccessDCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
Lung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung cancer progression with deleterious effects. DDB...
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Article
The Microstructure Evolution and Mechanical Properties of Al2O3/ZrO2 Coatings with Different ZrO2 Contents: Guidelines to Prepare Eutectic Powders
The Al2O3/ZrO2 coatings (AZ-Cs) with different ZrO2 contents were prepared via Al-Zr(NO3)4 combustion-assisted thermal spraying (CATS) method, and its microstructure evolution, mechanical properties were analyzed...
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Article
Open AccessNPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma
Lung cancer is the leading cause of cancer-related deaths worldwide, and despite recent advances in targeted therapies and immunotherapies, the clinical benefit remains limited. Therefore, there is an urgent n...
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Article
A comprehensive study on zirconia slurry for stereolithography-based additive manufacturing
Stereolithography-based additive manufacturing (AM) makes it possible to realize high-quality ceramic parts with various shapes. However, preparation of ceramic slurry with high solid loading, low viscosity, l...
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Article
Open AccessA phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, have achieved good efficacy in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients, but eventual drug ...
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Article
Open AccessLymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a
Lymph node metastasis (LNM), a common metastatic gastric-cancer (GC) route, is closely related to poor prognosis in GC patients. Bone marrow-derived mesenchymal stem cells (BM-MSCs) preferentially engraft at m...
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Article
Open AccessContinuous culture of urine-derived bladder cancer cells for precision medicine
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Article
Rapid decline of a relatively high latitude coral assemblage at Weizhou Island, northern South China Sea
“Refuge theory” suggests that global warming would be beneficial to corals in high latitude waters. In theory, then, the Weizhou Island reef (21°00′–21°10′N, 109°00′–109°15′E), which is located in a relatively...
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Article
NLRP3 Inflammasome Involves in the Acute Exacerbation of Patients with Chronic Obstructive Pulmonary Disease
The NLR pyrin domain-containing protein 3 (NLRP3) inflammasome, a multi-protein complex, produces the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which may contribute to the development of airway...
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Article
miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1
Cisplatin resistance is a major obstacle in the treatment of lung adenocarcinoma (LAD), and its mechanism has not been fully elucidated. Here, we report that miR-326 is downregulated in cisplatin-resistant A54...
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Article
Open AccessQuantitative analysis of pathogens in the lower respiratory tract of patients with chronic obstructive pulmonary disease
Bacterial infection of the lower respiratory tract is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and acute exacerbations of COPD (AECOPD). This study inve...
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Article
Open AccessmiR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung adenocarcinoma cells
MicroRNAs (miRNAs) have been identified as important posttranscriptional regulators involved in various biological and pathological processes of cells, but their association with tumor chemoresistance has not ...
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Article
MicroRNA-148a suppresses epithelial-to-mesenchymal transition by targeting ROCK1 in non-small cell lung cancer cells
Recent studies have implied that miRNAs act as crucial modulators for epithelial-to-mesenchymal transition (EMT). We found that miR-148a is significantly downregulated in non-small cell lung cancer (NSCLC) com...
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Protocol
Immunochemical Method for Cyclopiazonic Acid
Cyclopiazonic acid (CPA) Fig. 1) is a toxic, indole tetramic acid that was originally isolated from Penicillium cyclopium Westling (1) and subsequently reported to be produced by numerous species of Penicillium a...
