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Article
A New Chromone from Angelica dahurica
In this study, a new chromone, six coumarins, and a phenolic compound were isolated from a MeOH extract of an Angelica dahurica stems. Through the use of various spectral techniques, the structures of the isolate...
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Article
Open AccessPlasmodium vivax merozoite-specific thrombospondin-related anonymous protein (PvMTRAP) interacts with human CD36, suggesting a novel ligand–receptor interaction for reticulocyte invasion
The Plasmodium vivax merozoite restrictively invades immature erythrocytes, suggesting that its ligand(s) might interact with corresponding receptor(s) that are selectively abundant on reticulocytes to complete t...
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Article
Open AccessComputational prognostic evaluation of Alzheimer’s drugs from FDA-approved database through structural conformational dynamics and drug repositioning approaches
Drug designing is high-priced and time taking process with low success rate. To overcome this obligation, computational drug repositioning technique is being promptly used to predict the possible therapeutic e...
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Article
A New Chromone from Ostericum koreanum
A new chromone, methyl (R)-2-hydroxy-3-((S)-2-(2-hydroxypropan-2-yl)-4-methoxy-5-oxo-2,3-dihydro-5H-furo[3,2-g]chromen-7-yl)propanoate (named as osterichromone A (4)), along with known compounds hamaudol (1), ang...
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Article
Open AccessRing stage classification of Babesia microti and Plasmodium falciparum using optical diffraction 3D tomographic technique
Babesia is an intraerythrocytic parasite often misdiagnosed as a malaria parasite, leading to inappropriate treatment of the disease especially in co-endemic areas. In recent years, optical diffraction tomography...
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Article
A New Chromone from Angelica polymorpha
Phytochemical investigation of the MeOH extract of Angelica polymorpha stem led to the isolation of a new chromone (compound 9, named polymorphachromic acid). Based on various spectral analyses, including CD spec...
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Article
Two New Pterocarpans from Lespedeza tomentosa
A phytochemical study on the MeOH extract of Lespedeza tomentosa roots led to the discovery of two new pterocarpans (labelled tomentocarpan A and B), along with three known pterocarpans and a flavanone. The struc...
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Article
In silico screening of GABA aminotransferase inhibitors from the constituents of Valeriana officinalis by molecular docking and molecular dynamics simulation study
Modulation of γ-aminobutyric acid (GABA) levels has been required in various disorders. GABA itself cannot be directly introduced into central nervous system (CNS) because of the blood brain barrier; inhibitio...
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Article
3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney
We previously demonstrated that 3,4,5-trihydorxycinnamic acid (THC), a derivative of hydroxycinnamic acids, possesses protective effect in lipopolysaccharide (LPS)-induced endotoxemia models. However, the effe...
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Article
3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo
NF-E2-related factor 2 (Nrf2) has been demonstrated to be a key transcription factor regulating the anti-inflammatory genes including heme oxygenase-1 (HO-1) in experimental sepsis models. Based on the fact th...
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Article
Heat shock transcription factor-1 suppresses apoptotic cell death and ROS generation in 3-nitropropionic acid-stimulated striatal cells
Striatal neuronal cell death is one of the pathological features of Huntington’s disease (HD). Overexpression of some heat shock proteins (HSPs) has been reported to suppress the aggregate formation of mutant ...
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Protocol
Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation In Situ
A primary pathological hallmark of Alzheimer disease brain is the presence of neurofibrillary tangles, which are highly aggregated and insoluble accumulations of the microtubule-associated protein tau. Althoug...
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Article
A new isoflavone glycoside from the stem bark of Sophora japonica
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4′-O-β-d-glucosyl isoflavone, glycitein-4′-O-β-d-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structu...
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Article
Cytotoxic constituents from the bark of Salix hulteni
Eight compounds were isolated from the bark of Salix hulteni. Based on spectral data, the isolated compounds were identified as 4-hydroxyacetophenone (1), naringenin (2), aromadendrin (3), catechin (4), picein (5
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Article
Synthetic wogonin derivatives suppress lipopolysaccharide-induced nitric oxide production and hydrogen peroxide-induced cytotoxicity
Wogonin (5,7-dihydroxy-8-methoxyflavone) has been reported to exhibit a variety of biological properties including anti-inflammatory and neuroprotective functions. In this study, biological activities of diver...
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Article
Tissue transglutaminase is not involved in the aggregate formation of stably expressed α-synuclein in sh-sy5y human neuroblastoma cells
Intraneuronal deposition containing α-synuclein is implicated in the pathogenesis of synucleinopathies including Parkinsons disease (PD). Although it has been demonstrated that cytoplasmic inclusions of wild t...
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Article
Modulation of suppressive activity of lipopolysaccharide-induced nitric oxide production by glycosidation of flavonoids
Flavonoids have been demonstrated to exhibit a wide range of biological activities including anti-inflammatory and neuroprotective actions. Although a significant amount of flavonoids has been identified to be...
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Article
Inhibitory action of minocycline on lipopolysaccharide-lnduced release of nitric oxide and prostaglandin E2 in BV2 microglial cells
Microglia are the major inflammatory cells in the central nervous system and become activated in response to brain injuries such as ischemia, trauma, and neurodegenerative diseases including Alzheimer’s diseas...
