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Article
Open AccessSerum KL-6 levels predict the occurrence and severity of treatment-related interstitial lung disease in lung cancer
In this study, we aimed to investigate the feasibility of serum Krebs von den Lungen-6 (KL-6) as a potential biomarker for treatment-related ILD (TR-ILD) in lung cancer. We recruited patients with lung cancer ...
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Article
Open AccessA prospective patient registry to monitor safety, effectiveness, and utilisation of bedaquiline in patients with multidrug-resistant tuberculosis in South Korea
Multidrug-resistant tuberculosis (MDR-TB) represents a major public health concern, with an ongoing need for new effective treatments. Bedaquiline is an oral diarylquinoline that has shown encouraging treatmen...
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Article
Open AccessTreatment shortening of drug-sensitive pulmonary tuberculosis using high-dose rifampicin for 3 months after culture conversion (Hi-DoRi-3): a study protocol for an open-label randomized clinical trial
The standard treatment regimen for drug-sensitive tuberculosis (TB), comprising four companion drugs, requires a minimum duration of 6 months, and this lengthy treatment leads to poor adherence and increased t...
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Article
Open AccessEnhanced production of pinosylvin stilbene with aging of Pinus strobus callus and nematicidal activity of callus extracts against pinewood nematodes
Pinosylvin stilbenes are phenolic compounds mainly occurring in the Pinaceae family. We previously reported that the accumulation of two pinosylvin stilbene compounds, dihydropinosylvin methyl ether (DPME) and...
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Article
Inhibitory Mechanisms of Water Extract of Oplopanax elatus on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Murine Macrophage Cells
To study the anti-inflammatory action and cellular mechanism of Oplopanax elatus.
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Article
In silico screening of GABA aminotransferase inhibitors from the constituents of Valeriana officinalis by molecular docking and molecular dynamics simulation study
Modulation of γ-aminobutyric acid (GABA) levels has been required in various disorders. GABA itself cannot be directly introduced into central nervous system (CNS) because of the blood brain barrier; inhibitio...
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Article
Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation
During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibit...
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Article
Open AccessLocalization of bleeding sites in patients with hemoptysis based on their chest computed tomography findings: a retrospective cohort study
The aim of this study was to propose a localization strategy for bleeding sites in hemoptysis patients using their chest computed tomography (CT) findings.
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Article
Antiviral effects of Phyllanthus urinaria containing corilagin against human enterovirus 71 and Coxsackievirus A16 in vitro
Human enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are major causative agents of hand, foot, and mouth disease (HFMD) especially in infants and children under 5 years of age. Despite recent outbreaks of...
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Article
Analysis of predictors influencing indeterminate whole-blood interferon-gamma release assay results in patients with rheumatic diseases
Triggers of indeterminate results from interferon-gamma release assays (IGRA) in patients with rheumatic diseases are still elusive. The aim of the present study was to describe predictors of indeterminate re...
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Article
3,4,5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo
NF-E2-related factor 2 (Nrf2) has been demonstrated to be a key transcription factor regulating the anti-inflammatory genes including heme oxygenase-1 (HO-1) in experimental sepsis models. Based on the fact th...
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Article
A phase III concurrent chemoradiotherapy trial with cisplatin and paclitaxel or docetaxel or gemcitabine in unresectable non-small cell lung cancer: KASLC 0401
Concurrent chemoradiotherapy (CCRT) is recommended for the management of patients with unresectable non-small cell lung cancer (NSCLC). This prospective study aimed to compare the efficacy of concurrently deli...
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Article
Open AccessDifferences in classification of COPD group using COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores: a cross-sectional analyses
The GOLD 2011 document proposed a new classification system for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk...
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Article
Open AccessClinical characteristics and treatment outcomes of tuberculosis in the elderly: a case control study
The purpose of this study was to evaluate the differences in clinical characteristics and treatment outcomes between older and younger tuberculosis (TB) patients in Korea.
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Article
Open AccessPlasma N-terminal Pro-brain Natriuretic Peptide: A Prognostic Marker in Patients with Chronic Obstructive Pulmonary Disease
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are elevated in patients with secondary pulmonary hypertension and chronic lung disease with right ventricular overload. The aim of the presen...
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Article
Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity
Eleven compounds were isolated from the stem of Angelica gigas. On the basis of spectral data, these compounds were identified as isoimperatorin (1), 7-methoxy-5-prenyloxycoumarin (2), imperatorin (3), decursin (...
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Article
Serum cytokines and critical illness-related corticosteroid insufficiency
Little information exists regarding the association of specific cytokine levels and different subgroups of patients with critical illness-related corticosteroid insufficiency (CIRCI).
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Article
A new isoflavone glycoside from the stem bark of Sophora japonica
A new isoflavone glycoside, 6-methoxy-7-hydroxy-4′-O-β-d-glucosyl isoflavone, glycitein-4′-O-β-d-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structu...
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Article
Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products
Two new dihydrofuranoisoflavanones, 2′,4′,5-trihydroxy-[5″-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2″,3″:7,8)]-(3S)-isoflavanone (1) and 2′, 4′, 5-trihydroxy-[5″-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2″...
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Article
Antioxidant and antimicrobial activities of extracts from a medicinal plant, sea buckthorn
This study was performed to evaluate the antioxidant and antimicrobial activities from the methanol extracts of the root and stem of Hippophae rhamnoides and their further partitioned fractions including hexane, ...
