28 Result(s)
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Article
Open AccessTargeted mutagenesis of the herpesvirus fusogen central helix captures transition states
Herpesviruses remain a burden for animal and human health, including the medically important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heter...
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Open AccessStructural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans
Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the stru...
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Article
Open AccessPreviously uncharacterized rectangular bacterial structures in the dolphin mouth
Much remains to be explored regarding the diversity of uncultured, host-associated microbes. Here, we describe rectangular bacterial structures (RBSs) in the mouths of bottlenose dolphins. DNA staining reveale...
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Open AccessCryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
Huntington’s disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. While experiments with patient-derived induced pluripot...
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Open Access3D RNA-scaffolded wireframe origami
Hybrid RNA:DNA origami, in which a long RNA scaffold strand folds into a target nanostructure via thermal annealing with complementary DNA oligos, has only been explored to a limited extent despite its unique ...
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Article
Open AccessCryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin
Chaperonins are homo- or hetero-oligomeric complexes that use ATP binding and hydrolysis to facilitate protein folding. ATP hydrolysis exhibits both positive and negative cooperativity. The mechanism by which ...
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Article
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution
Single-particle cryogenic electron microscopy (cryo-EM) has become a standard technique for determining protein structures at atomic resolution1–3. However, cryo-EM studies of protein-free RNA are in their early ...
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Open AccessPublisher Correction: A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessA glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form poly...
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Open AccessStructure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone. Mechanisms by which Ric-8A catalyzes these ac...
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Open AccessUltra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-thermodynamic stability to solubil...
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Article
Open AccessTrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
TrkH is a bacterial ion channel implicated in K+ uptake and pH regulation. TrkH assembles with its regulatory protein, TrkA, which closes the channel when bound to ADP and opens it when bound to ATP. However, it ...
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Open AccessCryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution
Specimens below 50 kDa have generally been considered too small to be analyzed by single-particle cryo-electron microscopy (cryo-EM). The high flexibility of pure RNAs makes it difficult to obtain high-resolut...
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Open AccessProgramming molecular topologies from single-stranded nucleic acids
Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remai...
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Open AccessGENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging
Tomography has made a radical impact on diverse fields ranging from the study of 3D atomic arrangements in matter to the study of human health in medicine. Despite its very diverse applications, the core of to...
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Open AccessVisualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus
Marine cyanobacteria perform roughly a quarter of global carbon fixation, and cyanophages that infect them liberate some of this carbon during infection and cell lysis. Studies of the cyanobacterium Prochlorococc...
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Gating machinery of InsP3R channels revealed by electron cryomicroscopy
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubiquitous ion channels responsible for cytosolic Ca2+ signalling and essential for a broad array of cellular processes ranging from contraction to secretion, ...
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Open AccessErratum: Structural diversity of supercoiled DNA
Nature Communications, 6: Article number: 8440 (2015); Published: 12 October 2015; Updated: 29 October 2015 The original version of this Article contained an error in the spelling of the author Daniel J. Catan...
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Open AccessStructural diversity of supercoiled DNA
By regulating access to the genetic code, DNA supercoiling strongly affects DNA metabolism. Despite its importance, however, much about supercoiled DNA (positively supercoiled DNA, in particular) remains unkno...
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Correction: Corrigendum: Protruding knob-like proteins violate local symmetries in an icosahedral marine virus
Nature Communications 5: Article number: 4278 (2014); Published: 2 July 2014; Updated: 12 January 2015. The Protein Data Bank accession code provided in this Article is incorrect; the correct code is 4bml.
