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  1. Article

    Open Access

    Structural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans

    Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary target for vaccine and drug development. How the stru...

    David Chmielewski, Eric A. Wilson, Grigore Pintilie, Peng Zhao in Nature Communications (2023)

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    Article

    Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography

    Chikungunya virus (CHIKV) is a representative alphavirus causing debilitating arthritogenic disease in humans. Alphavirus particles assemble into two icosahedral layers: the glycoprotein spike shell embedded i...

    David Chmielewski, Michael F. Schmid, Graham Simmons, **g ** in Nature Microbiology (2022)