-
Article
Open AccessStructure of recombinant formate dehydrogenase from Methylobacterium extorquens (MeFDH1)
Formate dehydrogenase (FDH) is critical for the conversion between formate and carbon dioxide. Despite its importance, the structural complexity of FDH and difficulties in the production of the enzyme have mad...
-
Article
Open AccessA structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle
Proper cellular proteostasis, essential for viability, requires a network of chaperones and cochaperones. ATP-dependent chaperonin TRiC/CCT partners with cochaperones prefoldin (PFD) and phosducin-like protein...
-
Article
Structure of the human DICER–pre-miRNA complex in a dicing state
Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs (dsRNAs)1,2. Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRN...
-
Article
Evolutionary balance between foldability and functionality of a glucose transporter
Despite advances in resolving the structures of multi-pass membrane proteins, little is known about the native folding pathways of these complex structures. Using single-molecule magnetic tweezers, we here rep...
-
Article
Open AccessPublisher Correction: A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessA glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry, and between cells to form poly...
-
Article
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor
Fast chemical communication in the nervous system is mediated by neurotransmitter-gated ion channels. The prototypical member of this class of cell surface receptors is the cation-selective nicotinic acetylcho...
-
Article
Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes
Native electrospray-ionization mass spectrometry (native MS) measures biomolecules under conditions that preserve most aspects of protein tertiary and quaternary structure, enabling direct characterization of ...
-
Article
Reprogramming an ATP-driven protein machine into a light-gated nanocage
Natural protein assemblies have many sophisticated architectures and functions, creating nanoscale storage containers, motors and pumps1,2,3. Inspired by these systems, protein monomers have been engineered to se...
