24 Result(s)

Article

A prospective trial of mechanical physiotherapy for lumbar disk prolapse

Fifty consecutive patients with neuroradiologically confirmed lumbar disk prolapse, who responded to the first five daily physiotherapy sessions with pain centralization, were prospectively treated with mecha...

D. Brötz, W. Küker, E. Maschke, W. Wick, J. Dichgans, M. Weller in Journal of Neurology (2003)

Article

Expression and functional activity of osteoprotegerin in human malignant gliomas

Apo2L/TRAIL-based therapy is a promising experimental approach to the treatment of human malignant gliomas. Osteoprotegerin (OPG) is a soluble decoy receptor for Apo2L/TRAIL that antagonizes Apo2L/TRAIL-induce...

U. Naumann, W. Wick, R. Beschorner, R. Meyermann, M. Weller in Acta Neuropathologica (2004)

Article

Reply to Lorenz et al.: Osteoprotegerin in the central nervous system

U. Naumann, W. Wick, R. Beschorner, R. Meyermann, M. Weller in Acta Neuropathologica (2004)

Article

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O⁶-methylguanine

Methylating drugs such as temozolomide (TMZ) are widely used in the treatment of brain tumours (malignant gliomas). The mechanism of TMZ-induced glioma cell death is unknown. Here, we show that malignant gliom...

W P Roos, L F Z Batista, S C Naumann, W Wick, M Weller, C F M Menck, B Kaina in Oncogene (2007)

Article

Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice

The expression of inhibitor of apoptosis (IAP) family members contributes to the resistance of human cancers to apoptosis induced by radiotherapy and chemotherapy. We report that the infection of malignant gli...

U Naumann, O Bähr, H Wolburg, S Altenberend, W Wick, P Liston, A Ashkenazi… in Gene Therapy (2007)

Article

Tryptophan degradation in autoimmune diseases

Recent evidence points to tryptophan (Trp) degradation as a potent immunosuppressive mechanism involved in the maintenance of immunological tolerance. Both Trp depletion and downstream Trp catabolites (TCs) ap...

C. A. Opitz, W. Wick, L. Steinman, M. Platten in Cellular and Molecular Life Sciences (2007)

Article

Primäre ZNS-Lymphome

Primäre ZNS-Lymphome (PZNSL) gehören zu den seltenen Gehirntumoren. Sie machen etwa 3% aller primären intrakraniellen Neubildungen aus; das mediane Erkrankungsalter liegt zwischen 60 und 65 Jahren. PZNSL führe...

Prof. Dr. U. Schlegel, A. Korfel, E. Thiel, W. Wick, R. Kortmann… in Der Onkologe (2009)

Article

Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells

The dioxin/aryl hydrocarbon receptor (AhR) is a transcription factor, which has been attributed a role in human cancerogenesis, cell cycle progression and transforming growth factor-β (TGF-β) signaling. As TGF...

D Gramatzki, G Pantazis, J Schittenhelm, G Tabatabai, C Köhle, W Wick… in Oncogene (2009)

Article

Arterial hypertension and bevacizumab treatment in glioblastoma: no correlation with clinical outcome

A. Wick, N. Schäfer, N. Dörner, D. Schemmer, M. Platten… in Journal of Neuro-Oncology (2010)

Article

Comment to: Parametric Response Map as an Imaging Biomarker to Distinguish Progression from Pseudoprogression in High-Grade Glioma: Pitfalls in Perfusion MRI in Brain Tumors

Pseudoprogression is a recently recognized phenomenon which occurs mainly within the first 3 months after resection and radiochemotherapy of glioblastomas in up to 30% of cases. It refers to contrast enhanceme...

A. Radbruch, M. Bendszus, W. Wick, S. Heiland in Clinical Neuroradiology (2010)

Article

Neuroradiological Response Criteria for High-grade Gliomas

The recently introduced new response criteria of the response assessment in neuro-oncology (RANO) working group and its clinical implications are the topic of this article. Establishing this working group as a...

K. Lutz, A. Radbruch, B. Wiestler, P. Bäumer, W. Wick… in Clinical Neuroradiology (2011)

Article

Behandlung von Hirntumorpatienten

Obschon die Behandlung maligner Gliome mit modernen operativen und strahlentherapeutischen Verfahren, dem Einsatz alkylierender und antiangiogener Systemtherapie sowie ersten molekular basierten Therapieentsch...

Prof. Dr. M. Platten, W. Wick in Der Nervenarzt (2012)

Article

Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment

An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling ‘evasive resi...

M Weiler, P-N Pfenning, A-L Thiepold, J Blaes, L Jestaedt, J Gronych… in Oncogene (2013)

Article

A comprehensive analysis of vascular complications in 3,889 glioma patients from the German Glioma Network

Ischemic strokes, intracranial hemorrhages (ICH) and deep venous thromboembolism (DVT) are clinically important events in patients with gliomas. In this multicentre, noninterventional observational study, curr...

C. Seidel, B. Hentschel, M. Simon, O. Schnell, O. Heese… in Journal of Neurology (2013)

Article

Personalisierte Neuroonkologie

Der Therapie hirneigener Tumoren steht ein fundamentaler Umbruch bevor. Dieser Umbruch wird aktuell weniger durch den Einsatz neuer zielgerichteter Therapien als durch die Definition molekularer Marker getrage...

Prof. Dr. M. Platten, J.P. Steinbach, W. Wick in Der Nervenarzt (2013)

Article

Biologische Grundlagen der Gehirnmetastasierung

Bestehende Gehirnmetastasen, aber auch die Sorge davor, künftig an ihnen zu erkranken, werden zunehmend zu einer Einschränkung der Lebensqualität bzw. -erwartung von Patienten mit soliden Tumoren.

Prof. Dr. F. Winkler, W. Wick in Der Onkologe (2014)

Article

NDRG1 prognosticates the natural course of disease in WHO grade II glioma

There is a lack of relevant prognostic and predictive factors in neurooncology besides mutation of isocitrate dehydrogenase 1, codeletion of 1p/19q and promoter hypermethylation of O ^...

J. Blaes, M. Weiler, F. Sahm, B. Hentschel, M. Osswald… in Journal of Neuro-Oncology (2014)