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Article
Smart Sensing Supramolecular Coordination Polymer Based on New Viologen Ligand Exhibiting Multiple Solid Detection and Inducing Apoptosis Properties
Through the self-assembly of 1,1'-bis(3-cyanobenzyl)-[4,4'-bipyridine]-1,1'-diium (H2bcbpy·2Cl) and pyromellitic acid (H4BTC), a novel multifunctional and multichromic organic supramolecular coordination polymer ...
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Article
Crustal thickening and extension induced by the Great Sumatra–Andaman earthquake of 26 December 2004: revealed by the seismic moment tensor element Mrr
In a complex geological environment, it is generally difficult to assimilate a complete understanding of the main stress regime without being distracted by various fault configurations. In this study, we exami...
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Article
Hepatic metabolism of two α-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human
The In vitro metabolism of two α-1A-adrenergic antagonists, RWJ-69205 and RWJ-69471 (phthalimide-phenylpiperazine analogs), was assessed after 30 and 60 min incubations with rat, dog and human hepatic S9 fraction...
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Article
Metabolism and excretion of the antiepileptic/antimigraine drug, topiramate in animals and humans
The metabolism and excretion of 2,3:4,5-bis-0-(l-methylethylidene)-β-D-fructopyranose sulfamate (TOPAMAX®, topiramate, TPM) have been investigated in animals and humans. Radiolabeled [14C] TPM was orally administ...
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Article
Metabolism of the α-1A-adrenergic receptor antagonist, pyridine-phenylpiperazine analog (RWJ-69597), in rat, dog and human hepatic S9 factions -API-MS/MS identification of metabolites
The In vitro metabolism of the α-1A-adrenergic antagonist, RWJ-69597, an analog of pyridine-phenylpiperazines, was conducted after incubation with rat, dog and human hepatic S9 fractions in the presence of an NAD...
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Article
Metabolism of the new α-1A-adrenergic receptor antagonist, phthalimide-phenylpiperazine analog (RWJ-69442), in rat, dog and human hepatic S9 fractions, and in rats
The in vitro and in vivo metabolism of RWJ-69442, an α-1A-adrenergic receptor antagonist, was investigated after incubation with that, dog, and human hepatic S9 fractions in the presence of NADPH-generating syste...
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Article
Metabolism of the new nonbenzodiazepine anxiolytic agent, RWJ-51204, in mouse, rat, dog, monkey and human hepatic S9 fractions, and in rats, dogs and humans
The in vitro and in vivo metabolism of the nonbenzodiazepine anxiolytic agent, RWJ-51204 was investigated after incubation with mice, rat, dog, monkey, and human hepatic S9 fractions in the presence of NADPH-g...
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Article
Human hepatic metabolism of the anxiolytic agent, RWJ-51521 — API-MS/MS identification of metabolites
The In vitro metabolism of the anxiolytic agent, RWJ-51521 was conducted after incubation with human hepatic S9 fraction in the presence of an NADPH-generating system. Unchanged RWJ-51521 (30% of the sample) a...
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Article
Hepatic metabolism of the new antipsychotic agent, mazapertine, in rat — API-MS/MS identification of metabolites
The In vitro biotransformation of the antipsychotic agent, mazapertine was studied after incubation with rat hepatic S9 fraction in the presence of an NADPH-generating system. Unchanged mazapertine (42% of the...
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Article
In vitro biotransformation of the analgesic agent, RWJ-51784, in rat, dog and human
RWJ-51784, an analogue of phenyl isoindoles, is a new analgesic agent. The in vitro metabolism of RWJ-51784 was conducted using rat, dog and human hepatic S9 in the presence of an NADPH generating system, and ...
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Article
In Vitro metabolism of the analgesic agent, RWJ-37874, in rat and human
RWJ-37874, an analogue of aroyl(aminoacyl)pyrrole, is a new analgesic agent. The in vitro metabolism of RWJ-37874 was conducted using rat and human hepatic S9 in the presence of an NADPH generating systme, and...
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Article
In vitro metabolism of the analgesic agent, tramadol-N-oxide, in mouse, rat, and human
Tramadol-N-oxide (TNO, RWJ-38705) is a new analgesic agent, which is believed to produce its analgesic effect following metabolic conversion to tramadol. In the present study, API ionspray-MS and MS/MS techniq...
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Article
Evaluation of the excretion, and metabolism of the cardiotonic agent bemoradan in male rats and female beagle dogs
The excretion and metabolism of (±) [6-(3,4-dihydro-3-oxo-1,4[2H]-benzoxazine-yl)-2,3,4,5-tetrahydro-5-methylpyridazin-3-one] (bemoradan; RWJ-22867) have been investigated in male Long-Evans rats and female be...
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Article
Evaluation of the absorption, excretion, and metabolism of the antihypertensive agent RWJ-26899 in male and female CR wistar rats and beagle dogs
The absorption, excretion and metabolism of N-(2,6-dichlorophenyl)-β-[[(1-methylcyclohexyl)methoxy]methyl]-N-(phenylmethyl)-1-pyrrolidineethanamine (RWJ-26899; McN-6497) has been investigated in male and femal...
