14 Result(s)
within
W. Dai
Medicine & Public Health
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Article
Multifunctional nanocomposites MGO/FU-MI inhibit the proliferation of tumor cells and enhance the effect of chemoradiotherapy in vivo and in vitro
The limitation of surgery, radiotherapy and chemotherapy in the treatment of cancer and the rise of the application of nanomaterials in the field of biomedicine have promoted the application of various nanomat...
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Open AccessRisk factors of postoperative complications after emergency repair of incarcerated groin hernia for adult patients: a retrospective cohort study
This study aimed to explore risk factors of postoperative complications for adult patients with incarcerated groin hernia (IGH).
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Article
Open AccessMethamphetamine abuse impairs motor cortical plasticity and function
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain area...
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Tumor suppression function of FoxD3 in lung cancer
The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been ...
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Article
Open AccessSystemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung
Mitotic error-mediated chromosome instability (CIN) can lead to aneuploidy, chromothripsis, DNA damage and/or whole chromosome gain/loss. CIN may prompt rapid accumulation of mutations and genomic alterations....
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Mediastinal small cell carcinoma: a unique clinical entity?
Mediastinal small cell carcinoma (MSCC) is a rare tumor with limited published literature. In view of diagnostic confusion pertaining to this tumor, we investigated its origin, clinical features, management an...
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Article
Surgical management of secondary hyperparathyroidism: how to effectively reduce recurrence at the time of primary surgery
Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a suc...
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Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength
This study was to determine if antibody against sclerostin (Scl-Ab) could prevent glucocorticoid (GC)-induced osteoporosis in mice. We found that Scl-Ab prevented GC-induced reduction in bone mass and bone str...
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Open AccessHuntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin
Huntington’s disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symp...
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Article
Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass
We used an osteopenic adult ovariectomized (OVX) rat model to evaluate various sequential treatments for osteoporosis, using FDA-approved agents with complementary tissue-level mechanisms of action. Sequential...
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Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
Multiple DNA methylation changes in the cancer methylome are associated with the acquisition of drug resistance; however it remains uncertain how many represent critical DNA methylation drivers of chemoresista...
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Article
BubR1 is involved in regulation of DNA damage responses
Defective mitotic spindles or an impaired spindle–kinetochore interaction activates the spindle checkpoint. We have previously shown that BubR1 haplo-insufficiency results in enhanced genomic instability and tumo...
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Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells
Arsenic trioxide (As2O3), an effective drug for the treatment of acute promyelocytic leukemia (APL), can induce apoptosis and partial differentiation in APL cells in vitro and in vivo. However, As2O3 also induces...
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Article
The protective effect of hepatocyte growth-promoting factor (pHGF) against carbon tetrachloride-induced acute liver injury in rats: an ultrastructural study
The protective effect of hepatocyte growth-promoting factor (pHGF) against CCl4-induced acute hepatitis in rats was examined by light and electron microscopy. Hepatocyte growth-promoting factor, purified from in...
