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Chapter and Conference Paper
Greening the Public Realm: Incorporating Bio-Diversity into City Spaces
With the transformation of urban beautification from rapid growth to high-quality urbanization and ecology, biodiversity has increasingly become an important indicator for assessing urban living environment. I...
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Article
Multifunctional nanocomposites MGO/FU-MI inhibit the proliferation of tumor cells and enhance the effect of chemoradiotherapy in vivo and in vitro
The limitation of surgery, radiotherapy and chemotherapy in the treatment of cancer and the rise of the application of nanomaterials in the field of biomedicine have promoted the application of various nanomat...
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Article
Open AccessRisk factors of postoperative complications after emergency repair of incarcerated groin hernia for adult patients: a retrospective cohort study
This study aimed to explore risk factors of postoperative complications for adult patients with incarcerated groin hernia (IGH).
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Article
Open AccessMethamphetamine abuse impairs motor cortical plasticity and function
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and the prefrontal cortex. Effects of chronic drug exposure on other brain area...
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Article
Tumor suppression function of FoxD3 in lung cancer
The transcription factor forkhead box D3 (FoxD3) is a forkhead protein and serves as a transcriptional repressor. The functions of FoxD3 in embryogenesis and in the development of neural crest cells have been ...
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Article
Open AccessSystemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung
Mitotic error-mediated chromosome instability (CIN) can lead to aneuploidy, chromothripsis, DNA damage and/or whole chromosome gain/loss. CIN may prompt rapid accumulation of mutations and genomic alterations....
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Article
Mediastinal small cell carcinoma: a unique clinical entity?
Mediastinal small cell carcinoma (MSCC) is a rare tumor with limited published literature. In view of diagnostic confusion pertaining to this tumor, we investigated its origin, clinical features, management an...
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Article
Surgical management of secondary hyperparathyroidism: how to effectively reduce recurrence at the time of primary surgery
Successful parathyroidectomy (PTX) often results in a dramatic drop in the parathyroid hormone (PTH) levels, relieves the patient from clinical symptoms, and reduces mortality. Although PTX is generally a suc...
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Article
Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo
Oxidative stress has a critical role in the pathogenesis of vitiligo. However, the specific molecular mechanism involved in oxidative stress-induced melanocyte death is not well characterized. Given the powerf...
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Article
Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength
This study was to determine if antibody against sclerostin (Scl-Ab) could prevent glucocorticoid (GC)-induced osteoporosis in mice. We found that Scl-Ab prevented GC-induced reduction in bone mass and bone str...
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Article
Open AccessHuntington’s disease cerebrospinal fluid seeds aggregation of mutant huntingtin
Huntington’s disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symp...
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Article
Growth of non-polar Zn1−x Mg x O thin films with different Mg contents on r-plane sapphire substrates by plasma-assisted molecular beam epitaxy
We report the growth and characterization of a series of non-polar Zn1−x Mg x O thin films with different Mg contents, which have been prepared on r-plane sapphir...
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Article
Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass
We used an osteopenic adult ovariectomized (OVX) rat model to evaluate various sequential treatments for osteoporosis, using FDA-approved agents with complementary tissue-level mechanisms of action. Sequential...
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Article
Open AccessNicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability
Nicotine is able to activate mitogenic signalling pathways, which promote cell growth or survival as well as increase chemoresistance of cancer cells. However, the underlying mechanisms are not fully understood.
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Article
Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation
Calcium deficiency causes abnormal colonic growth and increases colon cancer risk with poorly understood mechanisms. Here we elucidate a novel signaling mechanism underlying the Ca2+ deficiency-induced epithelial...
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Article
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
Multiple DNA methylation changes in the cancer methylome are associated with the acquisition of drug resistance; however it remains uncertain how many represent critical DNA methylation drivers of chemoresista...
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Article
Pertechnetate diffusion in GMZ bentonite
99Tc is an important radionuclides related to repository safety assessment. The mobility pertechnetate (TcO4 −) can be reduced to immobility technetium(IV) hydrous oxides (TcO2·nH
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Article
Influence of dry density on HTO diffusion in GMZ bentonite
With the low permeability and high swelling property, Gaomiaozi (GMZ) bentonite is regarded as the favorable candidate backfilling material for a potential repository. The diffusion behaviors of HTO in GMZ ben...
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Article
Open AccessCpG-island methylation study of liver fluke-related cholangiocarcinoma
Genetic changes have been widely reported in association with cholangiocarcinoma (CCA), while epigenetic changes are poorly characterised. We aimed to further evaluate CpG-island hypermethylation in CCA at can...
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Chapter and Conference Paper
Failure knowledge based decision-making in product quality
Decision-making in product quality is indispensable in order to keep product development at the lowest risk. Based on discussion of the deficiencies of Quality Function Deployment (QFD) and Failure Modes and E...
