13 Result(s)
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Vladimir V. Kalinichenko
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Article
Open AccessIdentification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia
Mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, a lethal lung disease affecting newborns an...
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Article
Open AccessLung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling
Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA-sequencing we identifi...
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Article
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal non-transcriptional functions in various biological processes critical for cellular homeostasis. We previously foun...
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Open AccessEndothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through which EPCs stimulate lung angio...
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Article
FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma
The PAX3-FOXO1 fusion protein is the key oncogenic driver in fusion positive rhabdomyosarcoma (FP-RMS), an aggressive soft tissue malignancy with a particularly poor prognosis. Identifying key downstream targe...
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Article
Genome Editing for Rare Diseases
Significant numbers of patients worldwide are affected by various rare diseases, but the effective treatment options to these individuals are limited. Rare diseases remain underfunded compared with more common...
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Article
Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1
Osteoclasts have a unique bone-destroying capacity, playing key roles in steady-state bone remodeling and arthritic bone erosion. Whether the osteoclasts in these different tissue settings arise from the same ...
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Open AccessVagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation
The liver possesses a high regenerative capacity. Liver regeneration is a compensatory response overcoming disturbances of whole-body homeostasis provoked by organ defects. Here we show that a vagus-macrophage...
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Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature
Lung morphogenesis is a highly orchestrated process beginning with the appearance of lung buds on approximately embryonic day 9.5 in the mouse. Endodermally derived epithelial cells of the primitive lung buds ...
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Article
Open AccessNeuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism
Under insulin-resistant conditions such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. A liver–brain–pancreas neuronal relay plays an important role in this process. Here, we s...
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Article
Open AccessFOXF1 transcription factor promotes lung regeneration after partial pneumonectomy
FOXF1, a member of the forkhead box family of transcription factors, has been previously shown to be critical for lung development, homeostasis, and injury responses. However, the role of FOXF1 in lung regener...
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Article
Open AccessControl of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3
Appropriate regulation of regional uterine stromal cell decidualization in implantation, at the mesometrial triangle and secondary decidual zone (SDZ) locations, is critical for successful pregnancy, although ...
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Article
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
Using a sequence of growth-factor manipulations to mimic embryonic intestinal development in culture, a new study has successfully generated human intestinal tissue in vitro from embryonic and induced pluripotent...
